| Gene Symbol |
UBN1
|
| Entrez Gene |
29855
|
| Alt Symbol |
VT, VT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubinuclein 1
|
| Other Description |
HIRA-binding protein|ubinuclein-1|ubiquitously expressed nuclear protein
|
| Swissprots |
B7Z6D3 D3DUE8 Q13079 Q9NPG3 Q9P1P7
|
| Accessions |
AAF34869 EAW85249 EAW85250 Q9NPG3 AA742357 AF108460 AAF31755 AF108461 AAF31756 AK022652 AK056282 AK300131 BAH13219 AU120544 AW385352 BC013750 BC156176 AAI56177 BC157077 AAI57078 BG822152 BQ009566 BQ186272 CB242197 CN428658 CV574190 CV574862 U19346 AAA64188 XM_005255277 XP_005255334 XM_005255278 XP_005255335 XM_005255279 XP_005255336 XM_011522465 XP_011520767 XM_011522466 XP_011520768 XM_011522467 XP_011520769 XR_932826 XR_932827 NM_016936 NM_001079514 NP_001072982 NM_001288656 NP_001275585
|
| Function |
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
|
| Subcellular Location |
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
|
| Tissue Specificity |
Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:19029251}.
|