UBN1

Gene Symbol UBN1
Entrez Gene 29855
Alt Symbol VT, VT4
Species Human
Gene Type protein-coding
Description ubinuclein 1
Other Description HIRA-binding protein|ubinuclein-1|ubiquitously expressed nuclear protein
Swissprots B7Z6D3 D3DUE8 Q13079 Q9NPG3 Q9P1P7
Accessions AAF34869 EAW85249 EAW85250 Q9NPG3 AA742357 AF108460 AAF31755 AF108461 AAF31756 AK022652 AK056282 AK300131 BAH13219 AU120544 AW385352 BC013750 BC156176 AAI56177 BC157077 AAI57078 BG822152 BQ009566 BQ186272 CB242197 CN428658 CV574190 CV574862 U19346 AAA64188 XM_005255277 XP_005255334 XM_005255278 XP_005255335 XM_005255279 XP_005255336 XM_011522465 XP_011520767 XM_011522466 XP_011520768 XM_011522467 XP_011520769 XR_932826 XR_932827 NM_016936 NM_001079514 NP_001072982 NM_001288656 NP_001275585
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Subcellular Location Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Tissue Specificity Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:19029251}.

UBN-1 (C-20) - sc-12261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UBN-1 (N-21) - sc-12258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UBN-1 (UBN1G12) - sc-81420 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
UBN-1 (UBN1G12): sc-81420 Western Blot analysis of human recombinant UBN-1 fusion protein.

Anti-UBN1 antibody - ab101282 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UBN1 antibody (ab101282) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-UBN1 antibody [UBN1-02] - ab84953 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UBN1-02
Overlay histogram showing HeLa cells stained with ab84953 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab84953, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG ( 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-UBN1 antibody [UBN1G12] - ab50890 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UBN1G12
Anti-UBN1 antibody [UBN1G12] (ab50890) + Recombinant immunising peptide

Anti-VT/Stx antibody - ab188542 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
SDS-PAGE analysis stained with CBB:Lane 1. culture medium of VTECLane 2. crude extracts of VTEC cells 

Anti-UBN1 / Ubinuclein 1 Antibody - LS-C76657 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-UBN1 / Ubinuclein 1 Antibody (clone UBN1G12) - LS-C184284 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone UBN1G12

Anti-UBN1 / Ubinuclein 1 Antibody (clone UBN1-02) - LS-C112424 from LifeSpan Bioscience

Prices $290.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UBN1-02

Anti-UBN1 / Ubinuclein 1 Antibody (aa140-154) - LS-C155034 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
UBN1 antibody (1 ug/ml) staining of MOLT4 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-UBN1 / Ubinuclein 1 Antibody (aa974-1023) - LS-C81099 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-UBN1 / Ubinuclein 1 Antibody (clone UBN1G12) - LS-C342831 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UBN1G12
Western blot analysis of immunized recombinant protein, using anti-UBN1 monoclonal antibody.

Anti-UBN1 / Ubinuclein 1 Antibody (aa1084-1134) - LS-C286141 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Ubinuclein-1 by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-Ubinuclein-1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-UBN1 / Ubinuclein 1 Antibody (aa161-210) IHC-plus™ - LS-B11373 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UBN1 / Ubinuclein 1 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11373 concentration 10 ug/ml.

UBN1 Antibody - NBP1-49983 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UBN1 Antibody - NBP2-26142 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: UBN1 Antibody [NBP2-26142] - (1ug/ml) staining of MOLT4 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Monoclonal Anti-Ubinuclein 1 antibody produced in mouse - SAB4700752 from Sigma-Aldrich

Prices $185.50
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UBN1-02

Anti-UBN1 antibody produced in rabbit - SAB2102631 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-UBN1: <B>Cat. No.SAB2102631</B>: UBN1 in HeLa cell lysate with UBN1 antibody at 1.0 μg/mL.

Anti-Ubinuclein antibody produced in rabbit - SAB4501346 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-Ubinuclein: <B>Cat. No. SAB4501346</B>: Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Anti-Ubinuclein antibody. Cells on the left were treated with the Anti-Ubinuclein antibody. Cells on the right (negative control) were treated with both Anti-Ubinuclein antibody and the synthesized immunogen peptide.

UBN1 Antibody (OAEE00558) - OAEE00558 from Aviva Systems Biology

Prices $230.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UBN1-02

UBN1 antibody - C-terminal region (ARP47638_P050) - ARP47638_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Ubinuclein-1--ubinuclein-2-Antibody-internal-region - AF3797a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3797a (1 µg/ml) staining of MOLT4 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

UBN1 Antibody (OAAF02689) - OAAF02689 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Goat anti-Ubinuclein 1 / ubinuclein 2 middle region Antibody (OAEB02987) - OAEB02987 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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