UBN1

Gene Symbol UBN1
Entrez Gene 29855
Alt Symbol VT, VT4
Species Human
Gene Type protein-coding
Description ubinuclein 1
Other Description HIRA-binding protein|ubinuclein-1|ubiquitously expressed nuclear protein
Swissprots B7Z6D3 D3DUE8 Q13079 Q9NPG3 Q9P1P7
Accessions AAF34869 EAW85249 EAW85250 Q9NPG3 AA742357 AF108460 AAF31755 AF108461 AAF31756 AK022652 AK056282 AK300131 BAH13219 AU120544 AW385352 BC013750 BC156176 AAI56177 BC157077 AAI57078 BG822152 BQ009566 BQ186272 CB242197 CN428658 CV574190 CV574862 U19346 AAA64188 XM_005255277 XP_005255334 XM_005255278 XP_005255335 XM_005255279 XP_005255336 XM_011522465 XP_011520767 XM_011522466 XP_011520768 XM_011522467 XP_011520769 XR_932826 XR_932827 NM_016936 NM_001079514 NP_001072982 NM_001288656 NP_001275585
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Subcellular Location Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Tissue Specificity Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:19029251}.

UBN-1 CRISPR/Cas9 KO Plasmid (h) - sc-409910 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 HDR Plasmid (h) - sc-409910-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 Double Nickase Plasmid (h) - sc-409910-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 Double Nickase Plasmid (h2) - sc-409910-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 CRISPR Activation Plasmid (h) - sc-409910-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 CRISPR Activation Plasmid (h2) - sc-409910-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 Lentiviral Activation Particles (h) - sc-409910-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 Lentiviral Activation Particles (h2) - sc-409910-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBN-1 siRNA (h) - sc-106663 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBN-1 shRNA Plasmid (h) - sc-106663-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBN-1 shRNA (h) Lentiviral Particles - sc-106663-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBN1 RNAi - H00029855-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU070221 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22405 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22405 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11334 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11334

UBN1 siRNA (Human) - CRH9242 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBN1 - MBS8237060 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Ubn1 (NM_016936.3) - SHH439408 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UBN1(NM_001079514.1) - SHL112118 from Creative biogene

Category siRNA
Species Reactivities Human

Human UBN1 siRNA - orb269744 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBN1 shRNA Plasmid (Human) - CHH9242 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBN1 miRNA 3'UTR clone - MiUTR1H-10965 from Creative biogene

Species Reactivities Human

UBN1 miRNA 3'UTR clone - MiUTR4H-TG12723 from Creative biogene

Species Reactivities Human
Search more