KLHL12

Gene Symbol	KLHL12
Entrez Gene	59349
Alt Symbol	C3IP1, DKIR
Species	Human
Gene Type	protein-coding
Description	kelch-like family member 12
Other Description	CUL3-interacting protein 1|DKIR homolog|kelch-like protein 12|kelch-like protein C3IP1
Swissprots	B7Z7B8 Q53G59 Q9HBX5 A6NEN8
Accessions	EAW91444 EAW91445 EAW91446 EAW91447 EAW91448 Q53G59 AF190900 AAG17175 AF306687 AF306689 AK024412 BAB14914 AK027656 BAB55271 AK130662 AK223072 BAD96792 AK301791 BAH13554 BC003183 AAH03183 BC004175 AAH04175 DB461868 DC399782 EU446840 ABZ92369 HY269282 XM_011509835 XP_011508137 XM_011509836 XP_011508138 XM_011509837 XP_011508139 NM_001303051 NP_001289980 NM_001303109 NP_001290038 NM_021633 NP_067646
Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. {ECO:0000269|PubMed:16547521, ECO:0000269|PubMed:18303015, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:22358839}.
Subcellular Location	Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000269|PubMed:22358839}.
Tissue Specificity	Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. {ECO:0000269|PubMed:15383316, ECO:0000269|PubMed:16108817}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KLHL12 (2G2) Mouse mAb - 9406 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 2G2

KLHL12 (C-14) - sc-162992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KLHL12 (S-14) - sc-162994 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-C3IP1 antibody - ab14233 from Abcam Prices $406.00 Sizes 50 µg Host Chicken Clonality Polyclonal

Anti-KLHL12 Antibody (aa205-404) - LS-C77439 from LifeSpan Bioscience Prices $665.00 Sizes 50 µg Host Chicken Clonality Polyclonal

Anti-KLHL12 Antibody (aa376-404, AP) - LS-C261456 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa376-404, Biotin) - LS-C261457 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa376-404, APC) - LS-C261455 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa376-404, FITC) - LS-C261458 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa376-404, PE) - LS-C261460 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa376-404, Azide-free, HRP) - LS-C261459 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa150-200) - LS-C289619 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa375-404) - LS-C322516 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody - LS-C155577 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (N-Terminus) - LS-C145444 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa250-300) - LS-C289622 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (aa68-117) - LS-C186657 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLHL12 Antibody (clone 2G2) - LS-C169209 from LifeSpan Bioscience Prices $345.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2G2

Anti-KLHL12 Antibody (aa177-405, clone 5C12) - LS-C336810 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5C12

Anti-KLHL12 Antibody (aa177-405, clone 4C10) - LS-C338677 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4C10

Anti-KLHL12 Antibody (aa177-405, clone 1D2) - LS-C338788 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D2

Anti-KLHL12 Antibody (aa177-405, clone 1E6) - LS-C336799 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E6

Anti-KLHL12 Antibody (aa177-405, clone 4E1) - LS-C336809 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4E1

Anti-KLHL12 Antibody (aa376-404) - LS-C160011 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

KLHL12/C3IP1 Antibody - NB120-14233 from Novus Biologicals Prices $399.00 Sizes 50 µg Host Chicken Clonality Polyclonal

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