KLHL12

Gene Symbol	KLHL12
Entrez Gene	59349
Alt Symbol	C3IP1, DKIR
Species	Human
Gene Type	protein-coding
Description	kelch-like family member 12
Other Description	CUL3-interacting protein 1|DKIR homolog|kelch-like protein 12|kelch-like protein C3IP1
Swissprots	B7Z7B8 Q53G59 Q9HBX5 A6NEN8
Accessions	EAW91444 EAW91445 EAW91446 EAW91447 EAW91448 Q53G59 AF190900 AAG17175 AF306687 AF306689 AK024412 BAB14914 AK027656 BAB55271 AK130662 AK223072 BAD96792 AK301791 BAH13554 BC003183 AAH03183 BC004175 AAH04175 DB461868 DC399782 EU446840 ABZ92369 HY269282 XM_011509835 XP_011508137 XM_011509836 XP_011508138 XM_011509837 XP_011508139 NM_001303051 NP_001289980 NM_001303109 NP_001290038 NM_021633 NP_067646
Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. {ECO:0000269|PubMed:16547521, ECO:0000269|PubMed:18303015, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:22358839}.
Subcellular Location	Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000269|PubMed:22358839}.
Tissue Specificity	Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. {ECO:0000269|PubMed:15383316, ECO:0000269|PubMed:16108817}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® KLHL12 siRNA I - 9410 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® KLHL12 siRNA II - 9420 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

KLHL12 CRISPR/Cas9 KO Plasmid (h) - sc-412929 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 HDR Plasmid (h) - sc-412929-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 Double Nickase Plasmid (h) - sc-412929-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 Double Nickase Plasmid (h2) - sc-412929-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 CRISPR Activation Plasmid (h) - sc-412929-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 CRISPR Activation Plasmid (h2) - sc-412929-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 Lentiviral Activation Particles (h) - sc-412929-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 Lentiviral Activation Particles (h2) - sc-412929-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KLHL12 siRNA (h) - sc-88759 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KLHL12 shRNA Plasmid (h) - sc-88759-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KLHL12 shRNA (h) Lentiviral Particles - sc-88759-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU110461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11272 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11272 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09285 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09285

KLHL12 siRNA (Human) - CRJ1780 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human KLHL12 (NM_021633.2) - SHH326063 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human KLHL12(NM_021633.2) - SHL200654 from Creative biogene Category siRNA Species Reactivities Human

Human KLHL12 siRNA - orb272281 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KLHL12 shRNA Plasmid (Human) - CHJ1780 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KLHL12 miRNA 3'UTR clone - MiUTR1H-05369 from Creative biogene Species Reactivities Human

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