KLHL12

Gene Symbol	KLHL12
Entrez Gene	59349
Alt Symbol	C3IP1, DKIR
Species	Human
Gene Type	protein-coding
Description	kelch-like family member 12
Other Description	CUL3-interacting protein 1|DKIR homolog|kelch-like protein 12|kelch-like protein C3IP1
Swissprots	B7Z7B8 Q53G59 Q9HBX5 A6NEN8
Accessions	EAW91444 EAW91445 EAW91446 EAW91447 EAW91448 Q53G59 AF190900 AAG17175 AF306687 AF306689 AK024412 BAB14914 AK027656 BAB55271 AK130662 AK223072 BAD96792 AK301791 BAH13554 BC003183 AAH03183 BC004175 AAH04175 DB461868 DC399782 EU446840 ABZ92369 HY269282 XM_011509835 XP_011508137 XM_011509836 XP_011508138 XM_011509837 XP_011508139 NM_001303051 NP_001289980 NM_001303109 NP_001290038 NM_021633 NP_067646
Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. {ECO:0000269|PubMed:16547521, ECO:0000269|PubMed:18303015, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:22358839}.
Subcellular Location	Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000269|PubMed:22358839}.
Tissue Specificity	Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. {ECO:0000269|PubMed:15383316, ECO:0000269|PubMed:16108817}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C3IP1 full length protein - ab74979 from Abcam Category Protein Prices $192.00 Sizes 5 µg Source E. coli Species Human

Human C3IP1 full length protein - ab169886 from Abcam Category Protein Prices $577.00 Sizes 50 µg Source E. coli Species Human

KLHL12 Antibody Blocking Peptide - LS-E4937 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KLHL12 Antibody Blocking Peptide - LS-E12297 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KLHL12 Antibody Blocking Peptide - LS-E14289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KLHL12/C3IP1 Recombinant Protein - H00059349-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

KLHL12-Antibody-C-term-Blocking-Peptide - BP17327b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Klhl12 Blocking Peptide - 33R-2002 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Kelch-like protein 12 - H00059349-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Kelch-like protein 12 - H00059349-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KLHL12 fusion protein - ag6658 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KLHL12 fusion protein - Ag6785 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Kelch-like 12 (Drosophila), T7-tagged - KLHL12-2935H from Creative Biomart Category Protein Source E.coli.

Recombinant Human KLHL12 - KLHL12-26618TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Kelch-like protein 12(KLHL12) - CSB-YP700650HU CSB-EP700650HU CSB-BP700650HU CSB-MP700650HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

C3IP1, Recombinant Protein - MBS637581 from MyBioSource Category Protein Prices $475.00 Sizes 50 µg Source E Coli Species Human

KLHL12 Peptide, Human - M34GP08271H from Creative Peptides Category Peptide Source Synthetic. Species Human

Kelch-like protein 12 (KLHL12), Recombinant Protein - MBS1396631 from MyBioSource Category Protein Prices $1,365.00, $1,365.00, $1,585.00, $1,585.00, $2,270.00, $2,270.00, $2,735.00, $2,735.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more