Gene Symbol | CACNB1 |
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Entrez Gene | 782 |
Alt Symbol | CAB1, CACNLB1, CCHLB1 |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, beta 1 subunit |
Other Description | calcium channel voltage-dependent subunit beta 1|calcium channel, L type, beta 1 polypeptide|dihydropyridine-sensitive L-type, calcium channel beta-1 subunit|voltage-dependent L-type calcium channel subunit beta-1 |
Swissprots | Q8N3X9 Q9UD79 Q02641 Q9C085 Q02640 Q02639 O15331 A8K114 |
Accessions | AAB58779 AAB58780 AAB58781 CAA79824 CAA79825 EAW60556 EAW60557 EAW60558 EAW60559 EAW60560 EAW60561 EAW60562 EAW60563 EAW60564 Q02641 AA694045 AB054985 BAB21444 AB209176 BAD92413 AK127283 BAG54473 AK289729 BAF82418 AK297643 BAH12640 AK300666 BAH13323 AK312385 AY393857 AAQ97605 BC037311 AAH37311 BP217857 DQ891688 ABM82614 EU176608 ABW03409 L06110 AAA36167 L06111 AAA36168 L06112 AAA36169 M76560 AAA51894 M92301 AAA35631 M92302 AAA35632 M92303 AAA35633 XM_005257645 XP_005257702 XM_005257646 XP_005257703 XM_005257647 XP_005257704 XM_006722072 XP_006722135 XM_011525186 XP_011523488 NM_000723 NP_000714 NM_199247 NP_954855 NM_199248 NP_954856 |
Function | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. |
Subcellular Location | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. |
Tissue Specificity | Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. {ECO:0000269|PubMed:8107964}. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP β1 (D-15) - sc-32079 from Santa Cruz Biotechnology
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L-type Ca ++ CP β1 (N-16) - sc-32077 from Santa Cruz Biotechnology
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L-type Ca ++ CP β1A (A-18) - sc-15970 from Santa Cruz Biotechnology
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L-type Ca ++ CP β1A (H-50) - sc-25689 from Santa Cruz Biotechnology
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L-type Ca ++ CP β1B (Q-20) - sc-32080 from Santa Cruz Biotechnology
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L-type Ca ++ CP β1B (T-20) - sc-32081 from Santa Cruz Biotechnology
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L-type Ca ++ CP β1 (Y-2D68) - sc-134377 from Santa Cruz Biotechnology
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Anti-CACNB1 antibody - ab80991 from Abcam
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Anti-CACNB1 antibody - ab54919 from Abcam
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Anti-CACNB1 antibody - ab94336 from Abcam
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Anti-CACNB1 antibody - N-terminal - ab85879 from Abcam
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Anti-CACNB1 Antibody (aa21-70) IHC-plus⢠- LS-B926 from LifeSpan Bioscience
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Anti-CACNB1 Antibody - LS-C26752 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (clone S7-18) - LS-C152670 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa542-572, AP) - LS-C221601 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa542-572, APC) - LS-C221602 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa201-250) - LS-C40298 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (C-Terminus) - LS-C178855 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa542-572, FITC) - LS-C221604 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa542-572, Biotin) - LS-C221603 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (C-Terminus) - LS-C110196 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa143-192) - LS-C109985 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa542-572, Azide-free, HRP) - LS-C221605 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa395-444) - LS-C110056 from LifeSpan Bioscience
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Anti-CACNB1 Antibody (aa542-572, PE) - LS-C221606 from LifeSpan Bioscience
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