PHLDA2

Gene Symbol	PHLDA2
Entrez Gene	7262
Alt Symbol	BRW1C, BWR1C, HLDA2, IPL, TSSC3
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology-like domain, family A, member 2
Other Description	beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein\|imprinted in placenta and liver protein\|p17-BWR1C\|p17-Beckwith-Wiedemann region 1 C\|p17-Beckwith-Wiedemann region 1C\|pleckstrin homology-like domain family A member 2\|tumor suppressing subchromosomal transferable fragment cDNA 3\|tumor suppressing subtransferable candidate 3\|tumor-suppressing STF cDNA 3 protein\|tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein\|tumor-supressing STF cDNA 3
Swissprots	O00496 Q53GA4
Accessions	EAX02531 Q53GA4 AF001294 AAB86680 AF019953 AAC51912 AF035444 AAC17458 AI659266 AK223027 BAD96747 BC005034 AAH05034 CR407664 CAG28592 HQ448329 ADQ32809 NM_003311 NP_003302
Function	Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines. {ECO:0000269\|PubMed:10594239, ECO:0000269\|PubMed:10749982, ECO:0000269\|PubMed:13129680, ECO:0000269\|PubMed:15457853, ECO:0000269\|PubMed:9328465}.

TSSC3 (A-14) - sc-66296 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TSSC3 (C-14) - sc-66297 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TSSC3 (C-14): sc-66297. Western blot analysis of TSSC3 expression in JAR (A), JEG-3 (B) and Hep G2 (C) whole cell lysates.

TSSC3 (G-17) - sc-66299 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-TSSC3 antibody - ab99209 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human bronchial epithelial tissue labelling TSSC3 with ab99209 at 1/100. A Cy3-conjugate donkey anti-rabbit IgG (1/200) was used as the secondary antibody. Positive staining shown in the cytoplasm and membrane. Magnification: 20X. Exposure time: 0.5 - 2.0 seconds. Left - DAPI. Middle - TSSC3. Right - Merge.

Anti-TSSC3 antibody - ab58379 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab58379 TSSC3 antibody at 1ug/ml.

Anti-TSSC3 antibody - ab110935 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab110935, at a 1/50 dilution, staining TSSC3 in paraffin-embedded Human placenta tissue by Immunohistochemistry, in the absence (left) and presence (right) of the immunizing peptide.

Anti-TSSC3 antibody - C-terminal - ab134830 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Immunohistochemical analysis of Formalin-fixed, Paraffin-embedded Human Prostate tissue labelling TSSC3 with ab134830 at 3.75 µg/ml.

Anti-PHLDA2 / TSSC3 Antibody (aa90-119, AP) - LS-C266194 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa90-119, APC) - LS-C266195 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa90-119, Biotin) - LS-C266196 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa90-119, FITC) - LS-C266197 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa90-119, Azide-free, HRP) - LS-C266198 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa90-119, PE) - LS-C266199 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa81-130) - LS-C119093 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded human placenta, using PHLA2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-PHLDA2 / TSSC3 Antibody (aa1-152, Biotin) - LS-C297627 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (N-Terminus) - LS-C146041 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

PHLDA2 antibody LS-C146041 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-PHLDA2 / TSSC3 Antibody (aa9-140, Biotin) - LS-C297628 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (clone 5E3) - LS-C198376 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	5E3

Detection limit for recombinant GST tagged PHLDA2 is approximately 0.3 ng/ml as a capture antibody.

Anti-PHLDA2 / TSSC3 Antibody (C-Terminus) - LS-C108066 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

PHLDA2 antibody LS-C108066 Western blot of HT1080 cell lysate.

Anti-PHLDA2 / TSSC3 Antibody (aa1-152, FITC) - LS-C303252 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa9-140, FITC) - LS-C303254 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa89-119) - LS-C323997 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody - LS-C341993 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PHLDA2 / TSSC3 Antibody (aa1-152) - LS-C295970 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant PHLDA2 / TSSC3.

Anti-PHLDA2 / TSSC3 Antibody (aa9-140) - LS-C295973 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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