PHLDA2
| Gene Symbol | PHLDA2 |
|---|---|
| Entrez Gene | 7262 |
| Alt Symbol | BRW1C, BWR1C, HLDA2, IPL, TSSC3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pleckstrin homology-like domain, family A, member 2 |
| Other Description | beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein|imprinted in placenta and liver protein|p17-BWR1C|p17-Beckwith-Wiedemann region 1 C|p17-Beckwith-Wiedemann region 1C|pleckstrin homology-like domain family A member 2|tumor suppressing subchromosomal transferable fragment cDNA 3|tumor suppressing subtransferable candidate 3|tumor-suppressing STF cDNA 3 protein|tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein|tumor-supressing STF cDNA 3 |
| Swissprots | O00496 Q53GA4 |
| Accessions | EAX02531 Q53GA4 AF001294 AAB86680 AF019953 AAC51912 AF035444 AAC17458 AI659266 AK223027 BAD96747 BC005034 AAH05034 CR407664 CAG28592 HQ448329 ADQ32809 NM_003311 NP_003302 |
| Function | Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines. {ECO:0000269|PubMed:10594239, ECO:0000269|PubMed:10749982, ECO:0000269|PubMed:13129680, ECO:0000269|PubMed:15457853, ECO:0000269|PubMed:9328465}. |
TSSC3 CRISPR/Cas9 KO Plasmid (h) - sc-405686 from Santa Cruz Biotechnology
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TSSC3 HDR Plasmid (h) - sc-405686-HDR from Santa Cruz Biotechnology
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TSSC3 Double Nickase Plasmid (h) - sc-405686-NIC from Santa Cruz Biotechnology
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TSSC3 Double Nickase Plasmid (h2) - sc-405686-NIC-2 from Santa Cruz Biotechnology
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TSSC3 CRISPR Activation Plasmid (h) - sc-405686-ACT from Santa Cruz Biotechnology
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TSSC3 CRISPR Activation Plasmid (h2) - sc-405686-ACT-2 from Santa Cruz Biotechnology
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TSSC3 Lentiviral Activation Particles (h) - sc-405686-LAC from Santa Cruz Biotechnology
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TSSC3 Lentiviral Activation Particles (h2) - sc-405686-LAC-2 from Santa Cruz Biotechnology
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TSSC3 siRNA (h) - sc-63175 from Santa Cruz Biotechnology
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TSSC3 shRNA Plasmid (h) - sc-63175-SH from Santa Cruz Biotechnology
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TSSC3 shRNA (h) Lentiviral Particles - sc-63175-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16744 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16744 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02975 from Sigma-Aldrich
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PHLDA2 siRNA (Human) - CRH4962 from Cohesion Biosciences
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TSSC3 RNAi - H00007262-R01 from Novus Biologicals
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shRNA set against Human PHLDA2 (NM_003311.3) - SHH374940 from Creative biogene
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shRNA set against Human PHLDA2(NM_003311.3) - SHR112000 from Creative biogene
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PHLDA2 shRNA Plasmid (Human) - CHH4962 from Cohesion Biosciences
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PHLDA2 miRNA 3'UTR clone - MiUTR1H-07869 from Creative biogene
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