CD8B

Gene Symbol CD8B
Entrez Gene 926
Alt Symbol CD8B1, LEU2, LY3, LYT3, P37
Species Human
Gene Type protein-coding
Description CD8b molecule
Other Description CD8 antigen, beta polypeptide 1 (p37)|T lymphocyte surface glycoprotein beta chain|T-cell surface glycoprotein CD8 beta chain
Swissprots Q9UDB4 Q9UDB8 P14861 Q9UQ55 Q9UDB9 Q496E2 Q9UDB7 P10966 Q496E1 Q9UDC0 P14860 Q9UDB6 Q496E0 Q9UDB5 Q15980
Accessions AAA52283 AAB21668 AAB21669 AAB21670 AAB21671 AAB21672 AAD13877 AAK91556 AAK91557 AAY24019 CCF76959 CCF76960 CCF76961 CCF76962 P10966 AK303360 BAG64420 AK303595 BAG64610 AW296309 AW611750 BC100911 AAI00912 BC100912 AAI00913 BC100913 AAI00914 BC100914 AAI00915 BP392114 BQ004743 DB223179 DC405359 M36712 AAA35664 X13444 CAA31795 X13445 CAA31796 X13446 CAA31797 X13452 CAA31803 Y00805 CAA68750 XM_011533164 XP_011531466 NM_001178100 NP_001171571 NM_004931 NP_004922 NM_172101 NP_742099 NM_172102 NP_742100 NM_172213 NP_757362 NM_172099
Function Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Subcellular Location Isoform 7: Secreted {ECO:0000305}.
Tissue Specificity Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. {ECO:0000269|PubMed:8436166}.
Top Pathways Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation

CD8 (32-M4) - sc-1177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD8 (32-M4): sc-1177. Western blot analysis of CD8 expression in HuT 78 whole cell lysate.

CD8 (UCH-T4) - sc-1181 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD8 (UCH-T4): sc-1181. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human tonsil showing membrane staining of lymphocytes.

CD8-β (5F2) - sc-19994 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD8-β (5F2) PE: sc-19994 PE. FCM analysis of CCRF-HSB-2 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

CD8-β (F-5) - sc-25277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD8-β (F-5): sc-25277. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic, membrane and nuclear staining of cells in glomeruli and tubuli. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

CD8-β (C-16) - sc-1143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CD8-β (H-149) - sc-9147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD8-β (H-149): sc-9147. Western blot analysis of CD8-β expression in SUP-T1 whole cell lysate.

CD8-β (M-20) - sc-1144 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD8-β (M-20): sc-1144. Western blot analysis of CD8-β expression in BYDP whole cell lysate (A) and mouse thymus tissue extract (B).

Anti-CD8 beta antibody - ab191905 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD8 beta antibody (ab191905)Lane 1 : Jurkat whole cell lysateLane 2 : RAW 264.7 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-CD8 beta antibody - ab168798 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD8 beta antibody (ab168798) at 1 µg/mlLane 1 : CD8 beta transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-CD8 beta antibody - ab167561 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CD8 beta antibody (ab167561) at 1 µg/mlLane 1 : CD8 beta transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-CD8 beta antibody [2ST8.5H7] - ab23616 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2ST8.5H7

Anti-CD8 beta antibody - Aminoterminal end - ab71530 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CD8 beta antibody - Aminoterminal end (ab71530) at 1/60 dilution + K562 cell line lysates at 35 µg

Anti-CD8B antibody [EPR1152(2)] - ab109266 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1152(2)
All lanes : Anti-CD8B antibody [EPR1152(2)] (ab109266) at 1/1000 dilutionLane 1 : MOLT4 cell lysateLane 2 : HuT78 cell lysateLane 3 : Raji cell lysateLysates/proteins at 10 µg per lane.

Anti-CD8B antibody [EPR1152(2)] (Alexa Fluor® 488) - ab200330 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1152(2)
ab200330 staining CD8B in Jurkat cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200330 at 1/50 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-CD8B antibody [EPR1152(2)] (Alexa Fluor® 647) - ab200332 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1152(2)
ab200332 staining CD8B in Jurkat cells cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200332 at 1/50 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-CD8B antibody [EPR1152(2)] (HRP) - ab200331 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1152(2)
All lanes : Anti-CD8B antibody [EPR1152(2)] (HRP) (ab200331) at 1/5000 dilutionLane 1 : Hut-78 Whole Cell LysateLane 2 : Raji (Human Burkitt's lymphoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-CD8B antibody - C-terminal - ab170355 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CD8B antibody - C-terminal (ab170355) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-CD8B / CD8 Beta Antibody (RPE) - LS-C4056 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-CD8B / CD8 Beta Antibody (clone 341, PE) - LS-C4059 from LifeSpan Bioscience

Prices $485.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 341

Anti-CD8B / CD8 Beta Antibody - LS-C4055 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-CD8B / CD8 Beta Antibody - LS-C4060 from LifeSpan Bioscience

Prices $435.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-CD8B / CD8 Beta Antibody (FITC) - LS-C4061 from LifeSpan Bioscience

Prices $515.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-CD8B / CD8 Beta Antibody (PE) - LS-C4063 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CD8B / CD8 Beta Antibody (clone 341) - LS-C34543 from LifeSpan Bioscience

Prices $265.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 341

Anti-CD8B / CD8 Beta Antibody - LS-C12677 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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