CDK14

Gene Symbol CDK14
Entrez Gene 5218
Alt Symbol PFTAIRE1, PFTK1
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase 14
Other Description PFTAIRE protein kinase 1|cell division protein kinase 14|serine/threonine-protein kinase PFTAIRE-1
Swissprots B4DNM2 Q75N06 Q9UDR0 A6NK51 Q8N764 O94921 A8WFP6 Q75N22 B4DHG5 A4D1E6 Q9H3D7
Accessions AAF19245 AAM48566 AAS07411 AAS07412 EAL24162 EAW76872 EAW76873 EAW76874 O94921 AA883846 AB020641 BAA74857 AF119833 AAG43234 AK289782 BAF82471 AK295086 BAG58127 AK296406 BAG59071 AK297974 BAG60284 AK307484 AK316026 BAH14397 BC136476 AAI36477 BC136477 AAI36478 BC152388 AAI52389 BC152436 AAI52437 BC167152 AAI67152 BC167156 AAI67156 BM740394 BP336072 DB476188 DC325068 DC420282 DQ655962 DQ655963 DQ655964 DQ655965 DQ655966 DQ656060 HY179664 XM_005250436 XP_005250493 XM_005250438 XP_005250495 XM_005250439 XP_005250496 XM_011516306 XP_011514608 XM_011516307 XP_011514609 XR_927477 NM_001287135 NP_001274064 NM_001287136 NP_001274065 NM_001287137 NP_001274066 NM_012395 NP_036527
Function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}.
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
Tissue Specificity Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. {ECO:0000269|PubMed:11313143}.
Top Pathways Transcriptional misregulation in cancer

PFTAIRE-1 (C-3) - sc-376366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PFTAIRE-1 (C-3): sc-376366. Western blot analysis of PFTAIRE-1 expression in Hep G2 whole cell lysate.

PFTAIRE-1 (D-12) - sc-55736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PFTAIRE-1 (D-12): sc-55736. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

PFTAIRE-1 (H-140) - sc-50475 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PFTAIRE-1 (H-140): sc-50475. Western blot analysis of PFTAIRE-1 expression in SH-SY5Y whole cell lysate (A) and mouse brain (B) and mouse cerebellum (C) tissue extracts.

PFTAIRE-1 (Q-13) - sc-55738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PFTK1 antibody - ab104150 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PFTK1 antibody (ab104150) at 1/100 dilution + Mouse liver tissue lysates at 35 µg

Anti-PFTK1 antibody - ab67997 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PFTK1 antibody (ab67997) at 1/500 dilutionLane 1 : PFTK1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-PFTK1 antibody - ab128675 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PFTK1 antibody (ab128675) at 1 µg/ml + Mouse pancreas lysate at 10 µg

Anti-PFTK1 antibody - N-terminal - ab175489 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PFTK1 antibody - N-terminal (ab175489) at 1/1000 dilution + Mouse cerebellum tissue lysate at 35 µg

Anti-PFTK1 antibody - N-terminal - ab174513 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PFTK1 antibody - N-terminal (ab174513) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-PFTK1 / CDK14 Antibody (aa45-72, AP) - LS-C254394 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa45-72, APC) - LS-C254395 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa45-72, Azide-free, HRP) - LS-C254398 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa45-72, FITC) - LS-C254397 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa45-72, Biotin) - LS-C254396 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa45-72, PE) - LS-C254399 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa1-30, AP) - LS-C258861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (C-Terminus) - LS-C151465 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PFTK1 / CDK14 antibody Western Blot of Mouse Pancreas.

Anti-PFTK1 / CDK14 Antibody (aa1-30, APC) - LS-C258860 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa45-72) - LS-C157904 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Cdk14 Antibody western blot of K562 cell line lysates (35 ug/lane). The Mouse Cdk14 antibody detected the Mouse Cdk14 protein (arrow).

Anti-PFTK1 / CDK14 Antibody (aa1-30, FITC) - LS-C258863 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa1-30, Biotin) - LS-C258862 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa1-30, PE) - LS-C258866 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa1-30, Azide-free, HRP) - LS-C258864 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (N-Terminus, AP) - LS-C280784 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PFTK1 / CDK14 Antibody (aa1-30) - LS-C164999 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of hPFTK1-M1 in mouse liver tissue lysates (35 ug/lane). PFTK1 (arrow) was detected using the purified antibody.
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