CDK14
| Gene Symbol | CDK14 |
|---|---|
| Entrez Gene | 5218 |
| Alt Symbol | PFTAIRE1, PFTK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 14 |
| Other Description | PFTAIRE protein kinase 1|cell division protein kinase 14|serine/threonine-protein kinase PFTAIRE-1 |
| Swissprots | B4DNM2 Q75N06 Q9UDR0 A6NK51 Q8N764 O94921 A8WFP6 Q75N22 B4DHG5 A4D1E6 Q9H3D7 |
| Accessions | AAF19245 AAM48566 AAS07411 AAS07412 EAL24162 EAW76872 EAW76873 EAW76874 O94921 AA883846 AB020641 BAA74857 AF119833 AAG43234 AK289782 BAF82471 AK295086 BAG58127 AK296406 BAG59071 AK297974 BAG60284 AK307484 AK316026 BAH14397 BC136476 AAI36477 BC136477 AAI36478 BC152388 AAI52389 BC152436 AAI52437 BC167152 AAI67152 BC167156 AAI67156 BM740394 BP336072 DB476188 DC325068 DC420282 DQ655962 DQ655963 DQ655964 DQ655965 DQ655966 DQ656060 HY179664 XM_005250436 XP_005250493 XM_005250438 XP_005250495 XM_005250439 XP_005250496 XM_011516306 XP_011514608 XM_011516307 XP_011514609 XR_927477 NM_001287135 NP_001274064 NM_001287136 NP_001274065 NM_001287137 NP_001274066 NM_012395 NP_036527 |
| Function | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY. |
| Tissue Specificity | Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. {ECO:0000269|PubMed:11313143}. |
| Top Pathways | Transcriptional misregulation in cancer |
PFTAIRE-1 CRISPR/Cas9 KO Plasmid (h) - sc-403568 from Santa Cruz Biotechnology
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PFTAIRE-1 HDR Plasmid (h) - sc-403568-HDR from Santa Cruz Biotechnology
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PFTAIRE-1 Double Nickase Plasmid (h) - sc-403568-NIC from Santa Cruz Biotechnology
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PFTAIRE-1 Double Nickase Plasmid (h2) - sc-403568-NIC-2 from Santa Cruz Biotechnology
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PFTAIRE-1 CRISPR Activation Plasmid (h) - sc-403568-ACT from Santa Cruz Biotechnology
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PFTAIRE-1 CRISPR Activation Plasmid (h2) - sc-403568-ACT-2 from Santa Cruz Biotechnology
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PFTAIRE-1 Lentiviral Activation Particles (h) - sc-403568-LAC from Santa Cruz Biotechnology
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PFTAIRE-1 Lentiviral Activation Particles (h2) - sc-403568-LAC-2 from Santa Cruz Biotechnology
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PFTAIRE-1 siRNA (h) - sc-62779 from Santa Cruz Biotechnology
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PFTAIRE-1 shRNA Plasmid (h) - sc-62779-SH from Santa Cruz Biotechnology
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PFTAIRE-1 shRNA (h) Lentiviral Particles - sc-62779-V from Santa Cruz Biotechnology
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PFTAIRE-1 siRNA (h2) - sc-270491 from Santa Cruz Biotechnology
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PFTAIRE-1 shRNA Plasmid (h2) - sc-270491-SH from Santa Cruz Biotechnology
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PFTK1 RNAi - H00005218-R02 from Novus Biologicals
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MISSION® esiRNA - EHU087331 from Sigma-Aldrich
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MISSION® siRNA - SIHK1597 from Sigma-Aldrich
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MISSION® siRNA - SIHK1595 from Sigma-Aldrich
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MISSION® siRNA - SIHK1596 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5840 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5840 from Sigma-Aldrich
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CDK14 siRNA (Human) - CRH3487 from Cohesion Biosciences
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CDK14 - MBS8206028 from MyBioSource
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shRNA set against Human CDK14 (NM_012395.2) - SHH260513 from Creative biogene
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shRNA set against Human PFTK1(NM_012395.2) - SHR108222 from Creative biogene
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CDK14 shRNA Plasmid (Human) - CHH3487 from Cohesion Biosciences
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