CDK14

Gene Symbol	CDK14
Entrez Gene	5218
Alt Symbol	PFTAIRE1, PFTK1
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 14
Other Description	PFTAIRE protein kinase 1|cell division protein kinase 14|serine/threonine-protein kinase PFTAIRE-1
Swissprots	B4DNM2 Q75N06 Q9UDR0 A6NK51 Q8N764 O94921 A8WFP6 Q75N22 B4DHG5 A4D1E6 Q9H3D7
Accessions	AAF19245 AAM48566 AAS07411 AAS07412 EAL24162 EAW76872 EAW76873 EAW76874 O94921 AA883846 AB020641 BAA74857 AF119833 AAG43234 AK289782 BAF82471 AK295086 BAG58127 AK296406 BAG59071 AK297974 BAG60284 AK307484 AK316026 BAH14397 BC136476 AAI36477 BC136477 AAI36478 BC152388 AAI52389 BC152436 AAI52437 BC167152 AAI67152 BC167156 AAI67156 BM740394 BP336072 DB476188 DC325068 DC420282 DQ655962 DQ655963 DQ655964 DQ655965 DQ655966 DQ656060 HY179664 XM_005250436 XP_005250493 XM_005250438 XP_005250495 XM_005250439 XP_005250496 XM_011516306 XP_011514608 XM_011516307 XP_011514609 XR_927477 NM_001287135 NP_001274064 NM_001287136 NP_001274065 NM_001287137 NP_001274066 NM_012395 NP_036527
Function	Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}.
Subcellular Location	Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
Tissue Specificity	Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. {ECO:0000269|PubMed:11313143}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PFTK1 (CDK14)/CyclinY full length protein - ab177576 from Abcam Category Protein Prices $273.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PFTK1 full length protein - ab159098 from Abcam Category Protein Source Wheat germ Species Human

Human PFTK1 full length protein - ab167928 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PFTK1 protein fragment - ab159099 from Abcam Category Protein Source Wheat germ Species Human

PFTK1 / CDK14 Antibody Blocking Peptide - LS-E22623 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PFTK1 / CDK14 Antibody Blocking Peptide - LS-E9043 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PFTK1 / CDK14 Antibody Blocking Peptide - LS-E8454 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PFTK1 / CDK14 Antibody Blocking Peptide - LS-E6627 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PFTK1 / CDK14 Antibody Blocking Peptide - LS-E10328 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PFTK1 Protein - H00005218-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human PFTK1 Protein - H00005218-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PFTK1 Peptide - P2114 from Novus Biologicals Category Peptide Species Human

PFTK1 Peptide - P2331 from Novus Biologicals Category Peptide Species Human

PFTK1 Peptide - P2559 from Novus Biologicals Category Peptide Species Human

PFTK1-Antibody-N-term-P82-Blocking-Peptide - BP6780a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PFTK1-Antibody-C-term-Blocking-Peptide - BP7026b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PFTK1-Antibody-N-term-Blocking-Peptide - BP7168a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PFTK1-Antibody-N-term-Blocking-Peptide - BP7550a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

hPFTK1-M1-Antibody-Blocking-Peptide - BP9800b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PFTK1 / CDK14 - H00005218-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

PFTK1 / CDK14 - H00005218-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PFTK1 / CDK14 - H00005218-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PFTK1 fusion protein - ag16259 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PFTK1 fusion protein - ag17713 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CDK14/CyclinY, GST-tagged - CDK14-116H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

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