TBC1D4
| Gene Symbol | TBC1D4 |
|---|---|
| Entrez Gene | 9882 |
| Alt Symbol | AS160, NIDDM5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TBC1 domain family, member 4 |
| Other Description | Acrg embryonic lethality minimal region ortholog|TBC (Tre-2, BUB2, CDC16) domain-containing protein|TBC1 domain family member 4|akt substrate of 160 kDa |
| Swissprots | A7E2X8 B6ETN8 B6ETN9 Q68D14 O60343 Q5W0B9 B4DU25 B4E235 |
| Accessions | EAW80536 EAW80537 EAW80538 O60343 AB011175 BAA25529 AB449885 BAH16628 AK300468 BAG62187 AK304091 BAG64997 AK307493 AY211910 BC146300 AAI46301 BC151239 AAI51240 CA448893 CR749622 CAH18416 FM207106 CAR62509 FM207107 CAR62510 XM_005266603 XP_005266660 XM_005266605 XP_005266662 XM_006719903 XP_006719966 XM_011535331 XP_011533633 NM_001286658 NP_001273587 NM_001286659 NP_001273588 NM_014832 NP_055647 |
| Function | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18771725}. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells. |
| Tissue Specificity | Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. {ECO:0000269|PubMed:15304337, ECO:0000269|PubMed:18276765, ECO:0000269|PubMed:18771725}. |
Human TBC1D4 peptide - ab26327 from Abcam
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Human TBC1D4 peptide - ab23116 from Abcam
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TBC1D4 / AS160 Antibody Blocking Peptide - LS-E26250 from LifeSpan Bioscience
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TBC1D4 / AS160 Antibody Blocking Peptide - LS-E30427 from LifeSpan Bioscience
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TBC1D4 / AS160 Antibody Blocking Peptide - LS-E23294 from LifeSpan Bioscience
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TBC1D4 / AS160 Antibody Blocking Peptide - LS-E9619 from LifeSpan Bioscience
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TBC1D4-Antibody-N-term-Blocking-Peptide - BP8523a from Abgent, a WuXi AppTec company
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AS160 / TBC1D4 blocking peptide - GTX89152-PEP from GeneTex
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AS160 (phospho-Thr642) Blocking Peptide - abx063628 from Abbexa
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TBC1D4 Peptide - AC21-1082-P from Abcore
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AS160 Peptide - 45-298P from ProSci
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TBC1D4 Peptide - 4415P from ProSci
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TBC1D4 fusion protein - ag20341 from Proteintech Group
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TBC1D4 fusion protein - Ag20327 from Proteintech Group
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Recombinant Human TBC1D4, His-tagged - TBC1D4-3130H from Creative Biomart
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Recombinant Human TBC1D4, MYC/DDK-tagged - TBC1D4-16H from Creative Biomart
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AS160 (pT642) Blocking Peptide - CBP2434 from Cohesion Biosciences
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p-TBC1D4 (T642) Peptide - BS4293P from Bioworld Technology
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Recombinant Human TBC1 domain family member 4(TBC1D4) ,partial - CSB-YP023218HU CSB-EP023218HU CSB-BP023218HU CSB-MP023218HU from Cusabio
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AS160/TBC1 Blocking Peptide - 3954BP-50 from Biovision
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TBC1D4 / AS160 - TP312105 from Acris Antibodies
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TBC1 domain family member 4 (TBC1D4), partial, Recombinant Protein - MBS1157697 from MyBioSource
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AS160/TBC1, Peptide - MBS843511 from MyBioSource
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AS160/TBC1D4, Peptide - MBS425974 from MyBioSource
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TBC1D4 Protein - NBP2-38460PEP from Novus Biologicals
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