| Gene Symbol | TBC1D4 |
|---|---|
| Entrez Gene | 9882 |
| Alt Symbol | AS160, NIDDM5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TBC1 domain family, member 4 |
| Other Description | Acrg embryonic lethality minimal region ortholog|TBC (Tre-2, BUB2, CDC16) domain-containing protein|TBC1 domain family member 4|akt substrate of 160 kDa |
| Swissprots | A7E2X8 B6ETN8 B6ETN9 Q68D14 O60343 Q5W0B9 B4DU25 B4E235 |
| Accessions | EAW80536 EAW80537 EAW80538 O60343 AB011175 BAA25529 AB449885 BAH16628 AK300468 BAG62187 AK304091 BAG64997 AK307493 AY211910 BC146300 AAI46301 BC151239 AAI51240 CA448893 CR749622 CAH18416 FM207106 CAR62509 FM207107 CAR62510 XM_005266603 XP_005266660 XM_005266605 XP_005266662 XM_006719903 XP_006719966 XM_011535331 XP_011533633 NM_001286658 NP_001273587 NM_001286659 NP_001273588 NM_014832 NP_055647 |
| Function | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18771725}. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells. |
| Tissue Specificity | Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. {ECO:0000269|PubMed:15304337, ECO:0000269|PubMed:18276765, ECO:0000269|PubMed:18771725}. |
TBC1D4 CRISPR/Cas9 KO Plasmid (h) - sc-410489 from Santa Cruz Biotechnology
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TBC1D4 HDR Plasmid (h) - sc-410489-HDR from Santa Cruz Biotechnology
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TBC1D4 Double Nickase Plasmid (h) - sc-410489-NIC from Santa Cruz Biotechnology
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TBC1D4 Double Nickase Plasmid (h2) - sc-410489-NIC-2 from Santa Cruz Biotechnology
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TBC1D4 CRISPR Activation Plasmid (h) - sc-410489-ACT from Santa Cruz Biotechnology
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TBC1D4 CRISPR Activation Plasmid (h2) - sc-410489-ACT-2 from Santa Cruz Biotechnology
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TBC1D4 Lentiviral Activation Particles (h) - sc-410489-LAC from Santa Cruz Biotechnology
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TBC1D4 Lentiviral Activation Particles (h2) - sc-410489-LAC-2 from Santa Cruz Biotechnology
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TBC1D4 siRNA (h) - sc-61654 from Santa Cruz Biotechnology
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TBC1D4 shRNA Plasmid (h) - sc-61654-SH from Santa Cruz Biotechnology
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TBC1D4 shRNA (h) Lentiviral Particles - sc-61654-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21076 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21076 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11024 from Sigma-Aldrich
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TBC1D4 siRNA (Human) - CRH6629 from Cohesion Biosciences
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TBC1D4 - MBS8230645 from MyBioSource
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shRNA set against Human TBC1D4 (NM_014832.2) - SHH424020 from Creative biogene
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shRNA set against Human TBC1D4(NM_014832.2) - SHL058910 from Creative biogene
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Human TBC1D4 siRNA - orb267131 from Biorbyt
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TBC1D4 shRNA Plasmid (Human) - CHH6629 from Cohesion Biosciences
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TBC1D4 miRNA 3'UTR clone - MiUTR1H-10223 from Creative biogene
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