Gene Symbol | TBC1D4 |
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Entrez Gene | 9882 |
Alt Symbol | AS160, NIDDM5 |
Species | Human |
Gene Type | protein-coding |
Description | TBC1 domain family, member 4 |
Other Description | Acrg embryonic lethality minimal region ortholog|TBC (Tre-2, BUB2, CDC16) domain-containing protein|TBC1 domain family member 4|akt substrate of 160 kDa |
Swissprots | A7E2X8 B6ETN8 B6ETN9 Q68D14 O60343 Q5W0B9 B4DU25 B4E235 |
Accessions | EAW80536 EAW80537 EAW80538 O60343 AB011175 BAA25529 AB449885 BAH16628 AK300468 BAG62187 AK304091 BAG64997 AK307493 AY211910 BC146300 AAI46301 BC151239 AAI51240 CA448893 CR749622 CAH18416 FM207106 CAR62509 FM207107 CAR62510 XM_005266603 XP_005266660 XM_005266605 XP_005266662 XM_006719903 XP_006719966 XM_011535331 XP_011533633 NM_001286658 NP_001273587 NM_001286659 NP_001273588 NM_014832 NP_055647 |
Function | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18771725}. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells. |
Tissue Specificity | Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. {ECO:0000269|PubMed:15304337, ECO:0000269|PubMed:18276765, ECO:0000269|PubMed:18771725}. |
Phospho-AS160 (Ser588) (D8E4) Rabbit mAb - 8730 from Cell Signaling Technology
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Phospho-AS160 (Thr642) Antibody - 4288 from Cell Signaling Technology
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Phospho-AS160 (Thr642) (D27E6) Rabbit mAb - 8881 from Cell Signaling Technology
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Phospho-AS160 (Ser318) (D3D11) Rabbit mAb - 8619 from Cell Signaling Technology
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AS160 (C69A7) Rabbit mAb - 2670 from Cell Signaling Technology
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AS160 Antibody - 2447 from Cell Signaling Technology
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TBC1D4 (H-48) - sc-135256 from Santa Cruz Biotechnology
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TBC1D4 (N-17) - sc-47470 from Santa Cruz Biotechnology
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Anti-TBC1D4 (phospho S588) antibody - ab65754 from Abcam
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Anti-TBC1D4 (phospho T642) antibody - ab65753 from Abcam
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Anti-TBC1D4 (phospho T642) antibody - ab59173 from Abcam
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Anti-TBC1D4 (phospho T642) antibody [EPR2733(2)] - ab131214 from Abcam
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Anti-TBC1D4 antibody - ab24469 from Abcam
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Anti-TBC1D4 antibody - ab62487 from Abcam
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Anti-TBC1D4 antibody - ab115893 from Abcam
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Anti-TBC1D4 antibody - ab134744 from Abcam
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Anti-TBC1D4 antibody - ab134749 from Abcam
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Anti-TBC1D4 antibody - ab59121 from Abcam
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Anti-TBC1D4 antibody - ab91242 from Abcam
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Anti-TBC1D4 antibody [5E6] - ab119004 from Abcam
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Anti-TBC1D4 / AS160 Antibody (phospho-Thr642) - LS-C34921 from LifeSpan Bioscience
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Anti-TBC1D4 / AS160 Antibody (aa1178-1189) - LS-C63888 from LifeSpan Bioscience
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Anti-TBC1D4 / AS160 Antibody - LS-C126663 from LifeSpan Bioscience
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Anti-TBC1D4 / AS160 Antibody - LS-C147066 from LifeSpan Bioscience
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Anti-TBC1D4 / AS160 Antibody (phospho-Ser666) - LS-C125034 from LifeSpan Bioscience
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