| Gene Symbol | EIF4E |
|---|---|
| Entrez Gene | 1977 |
| Alt Symbol | AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 4E |
| Other Description | eIF-4E|eIF-4F 25 kDa subunit|eukaryotic translation initiation factor 4E-like 1|mRNA cap-binding protein |
| Swissprots | B7Z6V1 Q96E95 P06730 D6RCQ6 |
| Accessions | AAB07114 CAI79364 CBL95069 CBY65608 CBY65610 EAX06077 EAX06078 EAX06079 EAX06080 EAX06081 P06730 AJ844638 AK295083 BAH11967 AK300982 BAH13387 AV708571 BC012611 AAH12611 BC035166 AAH35166 BC043226 AAH43226 BC107715 AAI07716 BM849222 CA419184 DC388666 DQ890728 ABM81654 DQ893903 ABM84829 KJ534830 AHW56470 M15353 AAC13647 XM_006714126 XP_006714189 XM_006714127 XP_006714190 NM_001130678 NP_001124150 NM_001130679 NP_001124151 NM_001968 NP_001959 |
| Function | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}. |
| Subcellular Location | Cytoplasm, P-body {ECO:0000269|PubMed:20616046}. Cytoplasm {ECO:0000250}. |
| Top Pathways | Insulin signaling pathway, RNA transport, PI3K-Akt signaling pathway, mTOR signaling pathway |