EIF4E

Gene Symbol EIF4E
Entrez Gene 1977
Alt Symbol AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 4E
Other Description eIF-4E|eIF-4F 25 kDa subunit|eukaryotic translation initiation factor 4E-like 1|mRNA cap-binding protein
Swissprots B7Z6V1 Q96E95 P06730 D6RCQ6
Accessions AAB07114 CAI79364 CBL95069 CBY65608 CBY65610 EAX06077 EAX06078 EAX06079 EAX06080 EAX06081 P06730 AJ844638 AK295083 BAH11967 AK300982 BAH13387 AV708571 BC012611 AAH12611 BC035166 AAH35166 BC043226 AAH43226 BC107715 AAI07716 BM849222 CA419184 DC388666 DQ890728 ABM81654 DQ893903 ABM84829 KJ534830 AHW56470 M15353 AAC13647 XM_006714126 XP_006714189 XM_006714127 XP_006714190 NM_001130678 NP_001124150 NM_001130679 NP_001124151 NM_001968 NP_001959
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}.
Subcellular Location Cytoplasm, P-body {ECO:0000269|PubMed:20616046}. Cytoplasm {ECO:0000250}.
Top Pathways Insulin signaling pathway, RNA transport, PI3K-Akt signaling pathway, mTOR signaling pathway

SignalSilence ® eIF4E siRNA II - 6554 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Species Reactivities Human
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Fluorescein Conjugate) #6201 (-) or SignalSilence ® eIF4E siRNA I #6311 or SignalSilence ® eIF4E siRNA II #6554 (+), using eIF4E (C46H6) Rabbit mAb #2067 and α-Tubulin (11H10) Rabbit mAb #2125. The eIF4E (C46H6) Rabbit mAb confirms silencing of eIF4E expression and α-Tubulin (11H10) Rabbit mAb is used to control for loading and specificity of eIF4E siRNA.

SignalSilence® eIF4E siRNA I - 6311 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (50-100 transfections)
Species Reactivities Human
Western blot analysis of extracts from HeLa cells, untransfected or transfected with either nonspecific control siRNA or eIF4E siRNA. eIF4E was detected using eIF4E Antibody #9742, and eIF4B was detected using eIF4B Antibody #3592. The eIF4E Antibody confirms silencing of eIF4E expression, and the eIF4B Antibody is used to control for loading and siRNA specificity.

eIF4E CRISPR/Cas9 KO Plasmid (h) - sc-400415 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E HDR Plasmid (h) - sc-400415-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E Double Nickase Plasmid (h) - sc-400415-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E Double Nickase Plasmid (h2) - sc-400415-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E CRISPR Activation Plasmid (h) - sc-400415-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E CRISPR Activation Plasmid (h2) - sc-400415-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E Lentiviral Activation Particles (h) - sc-400415-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E Lentiviral Activation Particles (h2) - sc-400415-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF4E siRNA (h) - sc-35284 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF4E shRNA Plasmid (h) - sc-35284-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF4E shRNA (h) Lentiviral Particles - sc-35284-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF4E RNAi - H00001977-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN7775 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7775 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07994 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07994

EIF4E siRNA (Human) - CRH1367 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF4E - MBS8203746 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EIF4E (NM_001968.3) - SHH284637 from Creative biogene

Category siRNA
Species Reactivities Human

Human EIF4E siRNA - orb261869 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF4E shRNA Plasmid (Human) - CHH1367 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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