| Gene Symbol | ST6GALNAC4 |
|---|---|
| Entrez Gene | 27090 |
| Alt Symbol | IV, SIAT3-C, SIAT3C, SIAT7-D, SIAT7D, ST6GALNACIV, ST6GalNAc |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 |
| Other Description | NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2, 6-sialyltransferase alpha2,6-sialyltransferase|NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase IV|ST6 neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminidealpha-2,6-sialyltransferase 4|ST6GalNAc IV|alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase|sialyltransferase 3C|sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) |
| Swissprots | Q9UKU1 Q9H4F1 Q9NWU6 Q9Y3G4 Q5T9D0 Q9ULB9 Q9Y3G3 |
| Accessions | AAF32237 CAB44353 CAB44354 CAS91685 EAW87717 EAW87718 EAW87719 EAW87720 EAW87721 Q9H4F1 AB035172 BAA87034 AJ271734 CAC07404 AK000600 BAA91281 AK292049 BAF84738 BC036705 AAH36705 CB126299 F27902 XM_011518527 XP_011516829 XM_011518528 XP_011516830 XM_011518529 XP_011516831 XM_011518530 XP_011516832 XR_929762 NM_175039 NP_778204 NM_175040 NP_778205 NM_014403 |
| Function | Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
Sialyltransferase 7D CRISPR/Cas9 KO Plasmid (h) - sc-408859 from Santa Cruz Biotechnology
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Sialyltransferase 7D HDR Plasmid (h) - sc-408859-HDR from Santa Cruz Biotechnology
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Sialyltransferase 7D Double Nickase Plasmid (h) - sc-408859-NIC from Santa Cruz Biotechnology
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Sialyltransferase 7D Double Nickase Plasmid (h2) - sc-408859-NIC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7D CRISPR Activation Plasmid (h) - sc-408859-ACT from Santa Cruz Biotechnology
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Sialyltransferase 7D CRISPR Activation Plasmid (h2) - sc-408859-ACT-2 from Santa Cruz Biotechnology
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Sialyltransferase 7D Lentiviral Activation Particles (h) - sc-408859-LAC from Santa Cruz Biotechnology
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Sialyltransferase 7D Lentiviral Activation Particles (h2) - sc-408859-LAC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7D siRNA (h) - sc-63020 from Santa Cruz Biotechnology
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Sialyltransferase 7D shRNA Plasmid (h) - sc-63020-SH from Santa Cruz Biotechnology
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Sialyltransferase 7D shRNA (h) Lentiviral Particles - sc-63020-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20665 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20665 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04838 from Sigma-Aldrich
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ST6GALNAC4 siRNA (Human) - CRH8957 from Cohesion Biosciences
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ST6GALNAC4 - MBS827888 from MyBioSource
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shRNA set against Human ST6GALNAC4 (NM_175040.3) - SHH418944 from Creative biogene
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shRNA set against Human ST6GALNAC4(NM_175039.3) - SHL038646 from Creative biogene
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shRNA set against Human ST6GALNAC4(NM_175040.3) - SHL038664 from Creative biogene
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Human ST6GALNAC4 siRNA - orb269459 from Biorbyt
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ST6GALNAC4 shRNA Plasmid (Human) - CHH8957 from Cohesion Biosciences
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ST6GALNAC4 miRNA 3'UTR clone - MiUTR1H-09952 from Creative biogene
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ST6GALNAC4 miRNA 3'UTR clone - MiUTR1H-09953 from Creative biogene
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