TFEB

Gene Symbol	TFEB
Entrez Gene	7942
Alt Symbol	ALPHATFEB, BHLHE35, TCFEB
Species	Human
Gene Type	protein-coding
Description	transcription factor EB
Other Description	T-cell transcription factor EB|class E basic helix-loop-helix protein 35
Swissprots	Q7Z6P9 Q9BRJ5 Q9UJD8 Q709B3 P19484
Accessions	CAD59560 EAX04055 EAX04056 EAX04057 EAX04058 P19484 AA235980 AJ608786 CAE77681 AJ608787 CAE77672 AJ608788 CAE77673 AJ608789 CAE77674 AJ608790 CAE77675 AJ608791 CAE77676 AJ608792 CAE77677 AJ608793 CAE77678 AJ608794 CAE77679 AK095061 BAG52979 AK298390 BAG60625 AK310063 AW294760 BC006225 AAH06225 BC032448 AAH32448 BU527754 CT000098 EU446667 ABZ92196 M33782 AAA36730 XM_005249411 XP_005249468 XM_005249412 XP_005249469 XM_006715212 XP_006715275 XM_006715213 XP_006715276 XM_011514915 XP_011513217 XM_011514916 XP_011513218 NM_001167827 NP_001161299 NM_001271943 NP_001258872 NM_001271944 NP_001258873 NM_001271945 NP_001258874 NM_007162 NP_009093
Function	Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. {ECO:0000269|PubMed:19556463, ECO:00
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TFEB full length protein - ab152831 from Abcam Category Protein Source Wheat germ Species Human

TFEB Antibody Blocking Peptide - LS-E6305 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TFEB Blocking Peptide - LS-E25350 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TFEB Antibody Blocking Peptide - LS-E13980 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TFEB Antibody Blocking Peptide - LS-E21264 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TFEB Antibody Blocking Peptide - LS-E26402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TFEB Antibody Blocking Peptide - LS-E31261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TFEB-Antibody-Center-Blocking-Peptide - BP18994c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TFEB (internal) blocking peptide - GTX88723-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

TFEB (N Terminus) blocking peptide - GTX89922-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Goat anti TFEB antibody Immunizing peptide - orb16812 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TFEB peptide - orb218120 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog

TFEB Blocking Peptide - abx063451 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig

TFEB Peptide - AC21-0178-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TFEB Peptide - AC21-1241-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TFEB - H00007942-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

TFEB - H00007942-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

TFEB - H00007942-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

TFEB (N-term) Control Peptide - AP55647CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TFEB Peptide - 6801P from ProSci Category Peptide Species Human

TFEB Peptide - 45-159P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Transcription Factor EB Peptide - 46-906P from ProSci Category Peptide Species Human

TFEB fusion protein - ag4194 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TFEB, GST-tagged - TFEB-3202H from Creative Biomart Category Protein Source E.coli Species Human

TFEB Blocking Peptide - CBP2257 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig

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