| Gene Symbol |
AGK
|
| Entrez Gene |
55750
|
| Alt Symbol |
CATC5, CTRCT38, MTDPS10, MULK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acylglycerol kinase
|
| Other Description |
acylglycerol kinase, mitochondrial|hAGK|hsMuLK|multi-substrate lipid kinase|multiple substrate lipid kinase
|
| Swissprots |
Q96GC3 Q75KN1 Q53H12 Q9NP48
|
| Accessions |
AAS07537 AAS07538 CAE89682 EAL24020 EAW83972 EAW83973 Q53H12 AJ278150 CAB93536 AK001704 BAA91848 AK222769 BAD96489 AK299131 BAG61184 AK304502 BAG65310 BC009775 AAH09775 BC022777 AAH22777 DB032353 XM_005250023 XP_005250080 XM_011516397 XP_011514699 NM_018238 NP_060708
|
| Function |
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. {ECO:0000269|PubMed:15939762}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000269|PubMed:15939762, ECO:0000269|PubMed:16269826}.
|
| Tissue Specificity |
Highly expressed in muscle, heart, kidney and brain. {ECO:0000269|PubMed:15939762}.
|
| Top Pathways |
Glycerolipid metabolism
|