CRHR1

Gene Symbol CRHR1
Entrez Gene 1394
Alt Symbol CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
Species Human
Gene Type protein-coding
Description corticotropin releasing hormone receptor 1
Other Description CRH receptor 1|corticotropin-releasing factor receptor 1|corticotropin-releasing factor type 1 receptor|seven transmembrane helix receptor
Swissprots Q9UK64 B4DIE9 Q4QRJ1 Q13008 P34998
Accessions AAC69993 AAM55213 BAC06179 EAW93556 EAW93557 EAW93558 EAW93559 EAW93560 P34998 AB451466 BAG70280 AF180301 AAD52688 AF369651 AAL46631 AF369652 AAL46632 AF369653 AAL46633 AF374231 AAL39014 AK124894 AY429529 AY457172 AAR19768 BC037967 BC096836 AAH96836 CK299669 EU012435 ABV59309 EU176016 ABV80233 FJ200483 ACO54880 HM852949 AEI52959 HY150162 L23332 AAA35718 L23333 AAA35719 U16273 AAC50073 X72304 CAA51052 NM_001145146 NP_001138618 NM_001145147 NP_001138619 NM_001145148 NP_001138620 NM_001303018 NP_001289947 NM_001303020 NP_001289949 NM_004382 NP_004373
Function G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.
Tissue Specificity Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. {ECO:0000269|PubMed:8243652}.
Top Pathways Long-term depression, Neuroactive ligand-receptor interaction

CRF-RI (V-14) - sc-12381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CRF-RI (Q-20) - sc-12383 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CRF-RI (F-20) - sc-12382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CRF-RI/II (C-20) - sc-1757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CRF-RI/II (C-20): sc-1757. Western blot analysis of human recombinant CRF-RI fusion protein.

CRF-RI/II (H-215) - sc-5543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CRF-RI/II (H-215): sc-5543. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.

Anti-CRF1 antibody - ab59023 from Abcam

Prices $384.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab59023 (1/100) staining CRF1 in paraffin embedded mouse brain tissue sections. Tissues were fixed in paraformaldehyde and permeabilised with 0.3% Triton X100/TBS. Please refer to abreview for further experimental details.See Abreview

Anti-CRF1 antibody - ab77686 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CRF1 antibody (ab77686) at 0.1 µg/ml + human colon lysate (in RIPA buffer) at 35 µg

Anti-CRF1 antibody - ab136055 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-CRF1 antibody (ab136055) at 1/500 dilution + HeLa cell lysates at 30 µg

Anti-CRF1 antibody - ab115286 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Pars Intermedia formalin-fixed, paraffin-embedded tissue stained with ab115286 at 20 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CRFR1 / CRHR1 Antibody (Extracellular Domain) IHC-plus™ - LS-A6612 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRFR1 / CRHR1 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRFR1 / CRHR1 Antibody (N-Terminus) IHC-plus™ - LS-A6687 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRFR1 / CRHR1 antibody IHC of human brain, amygdala. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRFR1 / CRHR1 Antibody - LS-C35993 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CRFR1 / CRHR1 Antibody (APC) - LS-C35994 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CRFR1 / CRHR1 Antibody (clone 343919, PE) - LS-C35995 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 343919

Anti-CRFR1 / CRHR1 Antibody (aa250-263) - LS-C54682 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody (aa95-128, APC) - LS-C255423 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody (aa95-128, AP) - LS-C255424 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody (aa107-117) - LS-C61727 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of human colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CRFR1 / CRHR1 Antibody (aa95-128, Biotin) - LS-C255425 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody (aa95-128, FITC) - LS-C255426 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody (aa263-312) - LS-C146256 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRHR1 / CRF1 antibody LS-C146256 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

Anti-CRFR1 / CRHR1 Antibody (aa93-142) - LS-C146379 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRHR1 / CRF1 antibody LS-C146379 Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.

Anti-CRFR1 / CRHR1 Antibody (aa95-128, Azide-free, HRP) - LS-C255427 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody (aa95-128, PE) - LS-C255429 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRFR1 / CRHR1 Antibody - LS-C285481 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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