| Gene Symbol |
CRHR1
|
| Entrez Gene |
1394
|
| Alt Symbol |
CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
corticotropin releasing hormone receptor 1
|
| Other Description |
CRH receptor 1|corticotropin-releasing factor receptor 1|corticotropin-releasing factor type 1 receptor|seven transmembrane helix receptor
|
| Swissprots |
Q9UK64 B4DIE9 Q4QRJ1 Q13008 P34998
|
| Accessions |
AAC69993 AAM55213 BAC06179 EAW93556 EAW93557 EAW93558 EAW93559 EAW93560 P34998 AB451466 BAG70280 AF180301 AAD52688 AF369651 AAL46631 AF369652 AAL46632 AF369653 AAL46633 AF374231 AAL39014 AK124894 AY429529 AY457172 AAR19768 BC037967 BC096836 AAH96836 CK299669 EU012435 ABV59309 EU176016 ABV80233 FJ200483 ACO54880 HM852949 AEI52959 HY150162 L23332 AAA35718 L23333 AAA35719 U16273 AAC50073 X72304 CAA51052 NM_001145146 NP_001138618 NM_001145147 NP_001138619 NM_001145148 NP_001138620 NM_001303018 NP_001289947 NM_001303020 NP_001289949 NM_004382 NP_004373
|
| Function |
G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.
|
| Tissue Specificity |
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. {ECO:0000269|PubMed:8243652}.
|
| Top Pathways |
Long-term depression, Neuroactive ligand-receptor interaction
|