CRHR1

Gene Symbol	CRHR1
Entrez Gene	1394
Alt Symbol	CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
Species	Human
Gene Type	protein-coding
Description	corticotropin releasing hormone receptor 1
Other Description	CRH receptor 1|corticotropin-releasing factor receptor 1|corticotropin-releasing factor type 1 receptor|seven transmembrane helix receptor
Swissprots	Q9UK64 B4DIE9 Q4QRJ1 Q13008 P34998
Accessions	AAC69993 AAM55213 BAC06179 EAW93556 EAW93557 EAW93558 EAW93559 EAW93560 P34998 AB451466 BAG70280 AF180301 AAD52688 AF369651 AAL46631 AF369652 AAL46632 AF369653 AAL46633 AF374231 AAL39014 AK124894 AY429529 AY457172 AAR19768 BC037967 BC096836 AAH96836 CK299669 EU012435 ABV59309 EU176016 ABV80233 FJ200483 ACO54880 HM852949 AEI52959 HY150162 L23332 AAA35718 L23333 AAA35719 U16273 AAC50073 X72304 CAA51052 NM_001145146 NP_001138618 NM_001145147 NP_001138619 NM_001145148 NP_001138620 NM_001303018 NP_001289947 NM_001303020 NP_001289949 NM_004382 NP_004373
Function	G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.
Tissue Specificity	Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. {ECO:0000269|PubMed:8243652}.
Top Pathways	Long-term depression, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CRF1 full length protein - ab152297 from Abcam Category Protein Source Wheat germ Species Human

Human CRF1 peptide - ab113546 from Abcam Category Peptide Species Human

Human CRF1 protein fragment - ab114595 from Abcam Category Protein Source Wheat germ Species Human

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E989 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E26229 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E28404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E28405 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E23200 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E23199 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E26466 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E29151 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E29169 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CRFR1 / CRHR1 Antibody Blocking Peptide - LS-E29147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human CRHR1/CRF1 Protein - H00001394-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CRHR1/CRF1 Protein - H00001394-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human CRHR1/CRF1 Protein - H00001394-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

CRFR1-Antibody-Q103-Blocking-peptide - BP11441a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CRHR1 (aa 107 - 117) blocking peptide - GTX88961-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

CRHR1 (aa 250 - 263) blocking peptide - GTX89157-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Sheep, Bovine

Recombinant human Corticotropin-releasing factor receptor 1 (OPCA00058) - OPCA00058 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human CRHR1 protein - orb244130 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CRHR1 protein - orb245800 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

CRHR1 Blocking Peptide - abx062078 from Abbexa Category Peptide Species Human, Mouse, Rat

CRF1 Peptide - AC21-1060-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CRF1 Peptide - AC21-1304-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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