| Gene Symbol |
PCNT
|
| Entrez Gene |
5116
|
| Alt Symbol |
KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pericentrin
|
| Other Description |
kendrin|pericentrin-2|pericentrin-380|pericentrin-B
|
| Swissprots |
O43152 Q7Z7C9 O95613
|
| Accessions |
CBX47507 EAX09277 EAX09278 EAX09279 EAX09280 EAX09281 O95613 AB007862 BAA23698 AF515282 AAP46636 AK024009 BAB14772 AK093923 BAC04252 AK296731 BAG59318 AW452809 BC035913 AAH35913 BP311784 BP312870 DC345793 U52962 AAD10838 XM_005261124 XP_005261181 XM_005261129 XP_005261186 XM_011529593 XP_011527895 XM_011529594 XP_011527896 NM_006031 NP_006022
|
| Function |
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:22797915}. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
|
| Tissue Specificity |
Expressed in all tissues tested, including placenta, liver, kidney and thymus. {ECO:0000269|PubMed:10823944}.
|