BMPR2

Gene Symbol	BMPR2
Entrez Gene	659
Alt Symbol	BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
Species	Human
Gene Type	protein-coding
Description	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Other Description	BMP type II receptor|BMP type-2 receptor|BMPR-2|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4
Swissprots	Q53SA5 Q13161 Q16569 Q4ZG08 Q13873 Q585T8
Accessions	AAX76517 AAX88941 AAY24146 EAW70309 EAW70310 Q13873 AK023426 AK093832 AK123579 AK292430 BAF85119 AY277593 AAQ18032 BC018743 BC032011 BC035097 BC041039 BC043650 BC052985 AAH52985 BF063564 BG530017 BQ889263 BQ896556 BU176845 C15977 D50516 BAA09094 DA787547 DB233604 U20165 AAC50105 Z48923 CAA88759 XM_011511687 XP_011509989 XM_011511688 XP_011509990 NM_001204 NP_001195 NM_033346
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in heart and liver.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BMPR2 protein fragment - ab126926 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human BMPR2 protein fragment - ab151349 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source Mammalian Species Human

Human BMPR2 protein fragment - ab186092 from Abcam Category Protein Prices $147.00 Sizes 10 µg Source Mammalian Species Human

Human BMPR2 protein fragment - ab126025 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

BMPR2 Antibody Blocking Peptide - LS-E6800 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human BMPR-II Protein - H00000659-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BMPR-II Peptide - P0795 from Novus Biologicals Category Peptide Species Human

BMPR2-Antibody-N-term-Blocking-Peptide - BP2006a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human/Mouse BMPR-II Fc Chimera, CF - 811-BR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human PPH1 protein - orb180184 from Biorbyt Category Protein Prices $213.00, $408.00, $850.00, $1,088.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

BMPR2 peptide - orb218799 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

BMPR2 Blocking Peptide - abx064130 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

Human BMPR2 Protein - abx065590 from Abbexa Category Protein Source E.coli Species Human

BMPR2 - H00000659-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BMPR2 - H00000659-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BMPR2 - P5499 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

Bone Morphogenetic Protein Receptor Type IIBMPR-II - 19-C303 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

BMPR2 fusion protein - Ag5752 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

BMPR2 fusion protein - Ag5868 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human BMPR-II Protein - BP001606-C303 from Syd Labs Category Protein Prices $98.00, $180.00, $1,920.00 Sizes 10 µg, 50 µg, 1 mg Source HEK293-derived. Species Human

Recombinant Human BMPR2, Fc-His tagged - BMPR2-133H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human BMPR2, His tagged - BMPR2-134H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human BMPR2, His-tagged - BMPR2-10258H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human BMPR2, Fc-tagged, Biotinylated - BMPR2-556H from Creative Biomart Category Protein Source Human cells Species Human

Recombinant Human Bone Morphogenetic Protein Receptor, Type II, GST-tagged - BMPR2-993H from Creative Biomart Category Protein Species Human

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