BMPR2

Gene Symbol BMPR2
Entrez Gene 659
Alt Symbol BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
Species Human
Gene Type protein-coding
Description bone morphogenetic protein receptor, type II (serine/threonine kinase)
Other Description BMP type II receptor|BMP type-2 receptor|BMPR-2|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4
Swissprots Q53SA5 Q13161 Q16569 Q4ZG08 Q13873 Q585T8
Accessions AAX76517 AAX88941 AAY24146 EAW70309 EAW70310 Q13873 AK023426 AK093832 AK123579 AK292430 BAF85119 AY277593 AAQ18032 BC018743 BC032011 BC035097 BC041039 BC043650 BC052985 AAH52985 BF063564 BG530017 BQ889263 BQ896556 BU176845 C15977 D50516 BAA09094 DA787547 DB233604 U20165 AAC50105 Z48923 CAA88759 XM_011511687 XP_011509989 XM_011511688 XP_011509990 NM_001204 NP_001195 NM_033346
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in heart and liver.
Top Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells

BMPR2 Antibody - 6979 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using BMPR2 Antibody.

BMPR-II (E-1) - sc-393304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BMPR-II (E-1): sc-393304. Western blot analysis of BMPR-II expression in IMR-32 (A) and A-431 (B) whole cell lysates.

BMPR-II (G-17) - sc-5682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BMPR-II (G-17): sc-5682. Immunofluorescence staining of methanol-fixed Hep G2 cells showing membrane localization.

BMPR-II (H-300) - sc-20737 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BMPR-II (H-300): sc-20737. Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic staining of glandular cells.

BMPR-II (T-18) - sc-5683 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BMPR-II (T-18): sc-5683. Immunofluorescence staining of methanol-fixed Hep G2 cells showing membrane localization.

BMPR-II (Z-18) - sc-73752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
BMPR-II (Z-18): sc-73752. Western blot analysis of BMPR-II expression in IMR-32 whole cell lysate.

BMPR-II (G-24) - sc-130704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
BMPR-II (G-24): sc-130704. Western blot analysis of BMPR-II expression in mouse heart tissue extract.

Anti-BMPR2 antibody - ab96826 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab96826 stained MCF-7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab96826 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-BMPR2 antibody - ab124463 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BMPR2 antibody (ab124463) at 1/500 dilution + Raji cell lysate

Anti-BMPR2 antibody - ab106266 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab106266 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab106266, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-BMPR2 antibody - ab10862 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-BMPR2 antibody - ab115239 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BMPR2 antibody (ab115239) at 1 µg/ml (Milk blocking - 3%)Lane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Liver (Mouse) Tissue LysateLane 3 : Liver (Rat) Tissue LysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-BMPR2 antibody [1F12] - ab130206 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F12
Overlay histogram showing HepG2 cells stained with ab130206 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab130206, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-BMPR2 antibody [MM0060-9A10] - ab78422 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0060-9A10
ab78422 at 1/200 dilution, staining BMPR2 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-BMPR2 Antibody (clone 4A2) - LS-C196764 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A2
Detection limit for recombinant GST tagged BMPR2 is approximately 3 ng/ml as a capture antibody.

Anti-BMPR2 Antibody (aa27-150, Biotin) - LS-C297621 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody (aa27-150, FITC) - LS-C303245 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody - LS-C309622 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody (aa37-66) - LS-C329263 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody (aa27-56) - LS-C329266 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody - LS-C340954 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody (aa27-150) - LS-C293049 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant BMPR-II / BMPR2.

Anti-BMPR2 Antibody (aa667-951) - LS-C185483 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: NIH-3T3. 7.5% SDS PAGE. BMPR-II / BMPR2 antibody diluted at 1:1000.

Anti-BMPR2 Antibody - LS-C341688 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BMPR2 Antibody (N-Terminus) - LS-C347658 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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