BMPR2

Gene Symbol BMPR2
Entrez Gene 659
Alt Symbol BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
Species Human
Gene Type protein-coding
Description bone morphogenetic protein receptor, type II (serine/threonine kinase)
Other Description BMP type II receptor|BMP type-2 receptor|BMPR-2|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4
Swissprots Q53SA5 Q13161 Q16569 Q4ZG08 Q13873 Q585T8
Accessions AAX76517 AAX88941 AAY24146 EAW70309 EAW70310 Q13873 AK023426 AK093832 AK123579 AK292430 BAF85119 AY277593 AAQ18032 BC018743 BC032011 BC035097 BC041039 BC043650 BC052985 AAH52985 BF063564 BG530017 BQ889263 BQ896556 BU176845 C15977 D50516 BAA09094 DA787547 DB233604 U20165 AAC50105 Z48923 CAA88759 XM_011511687 XP_011509989 XM_011511688 XP_011509990 NM_001204 NP_001195 NM_033346
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in heart and liver.
Top Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells

BMPR-II CRISPR/Cas9 KO Plasmid (h) - sc-400895 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II HDR Plasmid (h) - sc-400895-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II Double Nickase Plasmid (h) - sc-400895-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II Double Nickase Plasmid (h2) - sc-400895-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II CRISPR Activation Plasmid (h) - sc-400895-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II CRISPR Activation Plasmid (h2) - sc-400895-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II Lentiviral Activation Particles (h) - sc-400895-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II Lentiviral Activation Particles (h2) - sc-400895-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BMPR-II siRNA (h) - sc-40220 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BMPR-II shRNA Plasmid (h) - sc-40220-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BMPR-II shRNA (h) Lentiviral Particles - sc-40220-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BMPR-II RNAi - H00000659-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BMPR-II RNAi - H00000659-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU050381 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU103811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0176 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0178 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0177 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN4010 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4010 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BMPR2 siRNA (Human) - CRH0454 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BMPR2 - MBS8218396 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BMPR2 (NM_001204.6) - SHH247178 from Creative biogene

Category siRNA
Species Reactivities Human

BMPR2 shRNA Plasmid (Human) - CHH0454 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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