Gene Symbol | SLC22A12 |
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Entrez Gene | 116085 |
Alt Symbol | OAT4L, RST, URAT1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 22 (organic anion/urate transporter), member 12 |
Other Description | organic anion transporter 4-like protein|renal-specific transporter|solute carrier family 22 (organic anion/cation transporter), member 12|solute carrier family 22 member 12|urate anion exchanger 1|urate transporter 1 |
Swissprots | Q19PF8 Q19PF7 G3XAN7 Q96DT2 Q96S37 Q19PF9 B7WPG1 Q19PG0 Q6UXW3 |
Accessions | AAK68156 ABF74569 ABF74570 ABF74571 ABF74572 ABF74573 CAC51145 EAW74271 EAW74272 EAW74273 EAW74274 EAW74275 EAW74276 Q96S37 AB050269 BAB68364 AB071863 BAB96750 AK055737 BAG51565 AK122599 BAG53617 AK309588 AK315061 AY358183 AAQ88550 BC026291 AAH26291 BC053348 AAH53348 BX104022 DA631511 DQ655911 DQ655912 XM_006718430 XP_006718493 XM_006718431 XP_006718494 NM_001276326 NP_001263255 NM_001276327 NP_001263256 NM_144585 NP_653186 NM_153378 NP_700357 |
Function | Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. {ECO:0000269|PubMed:12024214}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12024214}; Multi-pass membrane protein {ECO:0000269|PubMed:12024214}. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules. |
Tissue Specificity | Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex. {ECO:0000269|PubMed:12024214, ECO:0000269|PubMed:15304510}. |
Human SLC22A12 full length protein - ab165092 from Abcam
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Human SLC22A12 protein fragment - ab165093 from Abcam
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URAT1 / SLC22A12 Antibody Blocking Peptide - LS-E16207 from LifeSpan Bioscience
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Recombinant Human SLC22A12 Protein - H00116085-P01 from Novus Biologicals
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SLC22A12 Partial Recombinant Protein - H00116085-Q02 from Novus Biologicals
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SLC22A12 Blocking Peptide - 33R-8641 from Fitzgerald
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SLC22A12 / URAT1 - H00116085-P01 from Acris Antibodies
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SLC22A12 / URAT1 - H00116085-Q02 from Acris Antibodies
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SLC22A12 / URAT1 - H00116085-Q02-10 from Acris Antibodies
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SLC22A12 / URAT1 - H00116085-Q02-25 from Acris Antibodies
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URAT1 fusion protein - ag6770 from Proteintech Group
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Recombinant Urate Transporter 1 (URAT1) - RPE451Hu01 from Uscn Life Science Inc.
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Recombinant Urate Transporter 1 (URAT1) - RPE451Hu01 from Cloud-clone
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SLC22A12 Recombinant Protein Antigen - NBP1-82500PEP from Novus Biologicals
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SLC22A12 Peptide, Human - M34GP14376H from Creative Peptides
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Solute carrier family 22 member 12 (SLC22A12), Recombinant Protein - MBS7097555 from MyBioSource
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URAT1 fusion protein - Ag27805 from Proteintech Group
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