Gene Symbol | IFT27 |
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Entrez Gene | 11020 |
Alt Symbol | BBS19, RABL4, RAYL |
Species | Human |
Gene Type | protein-coding |
Description | intraflagellar transport 27 |
Other Description | RAB, member of RAS oncogene family-like 4|intraflagellar transport protein 27 homolog|rab-like protein 4 |
Swissprots | O60897 Q9BW83 |
Accessions | EAW60114 EAW60115 EAW60116 EAW60117 Q9BW83 AA809074 AB209424 BAD92661 AI215119 AK090708 AK307105 AK307382 AL022729 CAA18787 AW236857 BC000566 AAH00566 BM711121 BT006815 AAP35461 BX537634 CR456558 CAG30444 CU013158 CAK54589 CU013446 CAK54888 DB457924 DB502180 XM_006724106 XP_006724169 NM_001177701 NP_001171172 NM_006860 NP_006851 NR_033531 NM_001177702 |
Function | Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity). {ECO:0000250|UniProtKB:A8HN58, ECO:0000269|PubMed:25443296}. |
Subcellular Location | Cell projection, cilium {ECO:0000269|PubMed:25443296}. |
Rab L4 CRISPR/Cas9 KO Plasmid (h) - sc-409803 from Santa Cruz Biotechnology
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Rab L4 HDR Plasmid (h) - sc-409803-HDR from Santa Cruz Biotechnology
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Rab L4 Double Nickase Plasmid (h) - sc-409803-NIC from Santa Cruz Biotechnology
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Rab L4 Double Nickase Plasmid (h2) - sc-409803-NIC-2 from Santa Cruz Biotechnology
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Rab L4 CRISPR Activation Plasmid (h) - sc-409803-ACT from Santa Cruz Biotechnology
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Rab L4 CRISPR Activation Plasmid (h2) - sc-409803-ACT-2 from Santa Cruz Biotechnology
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Rab L4 Lentiviral Activation Particles (h) - sc-409803-LAC from Santa Cruz Biotechnology
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Rab L4 Lentiviral Activation Particles (h2) - sc-409803-LAC-2 from Santa Cruz Biotechnology
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Rab L4 siRNA (h) - sc-76330 from Santa Cruz Biotechnology
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Rab L4 shRNA Plasmid (h) - sc-76330-SH from Santa Cruz Biotechnology
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Rab L4 shRNA (h) Lentiviral Particles - sc-76330-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10503 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10503 from Sigma-Aldrich
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IFT27 siRNA (Human) - CRH7529 from Cohesion Biosciences
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IFT27 - MBS8215671 from MyBioSource
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shRNA set against Human IFT27 (NM_006860.4) - SHH317293 from Creative biogene
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IFT27 shRNA Plasmid (Human) - CHH7529 from Cohesion Biosciences
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IFT27 miRNA 3'UTR clone - MiUTR3H-15146 from Creative biogene
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