CUL1

Gene Symbol CUL1
Entrez Gene 8454
Alt Symbol -
Species Human
Gene Type protein-coding
Description cullin 1
Other Description CUL-1|cullin-1
Swissprots D3DWG3 Q08AL6 O60719 Q13616 Q8IYW1
Accessions AAM49153 AAS02034 EAL24422 EAW80072 EAW80073 EAW80074 Q13616 AF062536 AAC36681 AK096163 BAG53222 AK096505 BAG53307 AK296909 BAG59465 AK315023 AM393444 CAL38322 AM393566 CAL38443 BC034318 BC125119 AAI25120 BC125120 AAI25121 BG391038 BX537409 CAD97651 CA945052 U58087 AAC50544 XM_005250060 XP_005250117 XM_011516629 XP_011514931 XM_011516630 XP_011514932 XM_011516631 XP_011514933 XM_011516632 XP_011514934 NM_003592 NP_003583
Function Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFK
Tissue Specificity Expressed in lung fibroblasts. {ECO:0000269|PubMed:9663463}.
Top Pathways Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm

CUL1 Antibody - 4995 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MDA-MB-231, MDA-MB-468 and PC12 cells using CUL1 Antibody.

CUL-1 (AS97) - sc-12761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUL-1 (AS97): sc-12761. Western blot analysis of CUL-1 expression in JAR whole cell lysate.

CUL-1 (D-5) - sc-17775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUL-1 (D-5): sc-17775. Western blot analysis of CUL-1 expression in non-transfected 293T: sc-117752 (A), mouse CUL-1 transfected 293T: sc-119515 (B) and HeLa (C) whole cell lysates.

CUL-1 (N-19) - sc-8552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUL-1 (N-19): sc-8552. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic and nuclear staining of pneumocytes and cytoplasmic staining of macrophages.

CUL-1 (H-213) - sc-11384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CUL-1 (H-213): sc-11384. Western blot analysis of CUL-1 expression in JAR (A) and HOS (B) whole cell lysates.

CUL-1 (19) - sc-135874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CUL-1 (19): sc-135874. Western blot analysis of CUL-1 expression in P19 whole cell lysate.

Anti-Cullin 1 antibody - ab85152 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Cullin 1 antibody (ab85152) at 1/500 dilution + HeLa cell lysate

Anti-Cullin 1 antibody - ab1868 from Abcam

Prices $372.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-Cullin 1 antibody - ab115354 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab115354, at 1/500 dilution, staining Cullin 1 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Cullin 1 antibody - ab53049 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cullin 1 antibody (ab53049) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HeLa cell extract with immunising peptide

Anti-Cullin 1 antibody [AS97.1] - ab115187 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AS97.1

Anti-Cullin 1 antibody [AS97.1] - ab11047 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone AS97.1

Anti-Cullin 1 antibody [EPR3102Y] - ab75812 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3102Y
ab75812 at 1/100 dilution staining Cullin 1 in HeLa cells by Immunofluorescence.

Anti-Cullin 1 antibody [EPR3103Y] - ab75817 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3103Y
ab75817 at 1/100 dilution staining Cullin 1 in human cervical carcinoma by Immunohistochemistry, Paraffin-embedded tissue.

Anti-Cullin 1 antibody [EPR3103Y] (Alexa Fluor® 488) - ab201514 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3103Y
ab201514 staining Cullin 1 in HeLa cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab201514 at a 1/50 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HeLa cells fixed with 100% methanol (5 min).

Anti-Cullin 1 antibody, prediluted - ab15193 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Colon carcinoma stained with ab15193.

Anti-Cullin 1 antibody - C-terminal - ab199415 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cullin 1 antibody - C-terminal (ab199415) at 1/1000 dilutionLane 1 : MDA-MB-231 cell line lysateLane 2 : MDA-MB-468 cell line lysateLysates/proteins at 35 µg per lane.Secondarygoat anti-rabbit IgG H&L (HRP) at 1/5000 dilution

Anti-Cullin 1 antibody - C-terminal - ab189273 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis HeLa cells, labeling Cullin 1 using ab189273 at a 1/100 dilution. The picture on the right is treated with the synthesized peptide.

Anti-Cullin 1 / CUL1 Antibody (C-Terminus) - LS-C6251 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 1 / CUL1 Antibody (clone AS97.1) - LS-C63155 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone AS97.1

Anti-Cullin 1 / CUL1 Antibody (C-Terminus) - LS-C128429 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 1 / CUL1 Antibody (C-Terminus) - LS-C31412 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-Cullin 1 / CUL1 Antibody (C-Terminus) - LS-C182551 from LifeSpan Bioscience

Host Human
Clonality Polyclonal

Anti-Cullin 1 / CUL1 Antibody (C-Terminus) - LS-C188945 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 1 / CUL1 Antibody (aa679-708, APC) - LS-C208700 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Search more