CUL1

Gene Symbol	CUL1
Entrez Gene	8454
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cullin 1
Other Description	CUL-1|cullin-1
Swissprots	D3DWG3 Q08AL6 O60719 Q13616 Q8IYW1
Accessions	AAM49153 AAS02034 EAL24422 EAW80072 EAW80073 EAW80074 Q13616 AF062536 AAC36681 AK096163 BAG53222 AK096505 BAG53307 AK296909 BAG59465 AK315023 AM393444 CAL38322 AM393566 CAL38443 BC034318 BC125119 AAI25120 BC125120 AAI25121 BG391038 BX537409 CAD97651 CA945052 U58087 AAC50544 XM_005250060 XP_005250117 XM_011516629 XP_011514931 XM_011516630 XP_011514932 XM_011516631 XP_011514933 XM_011516632 XP_011514934 NM_003592 NP_003583
Function	Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFK
Tissue Specificity	Expressed in lung fibroblasts. {ECO:0000269|PubMed:9663463}.
Top Pathways	Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human CUL1 / Cullin 1 ELISA Kit (Cell-Based ELISA) - LS-F1920 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-Cul1 Antibody, Affinity Purified - PLA0277 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Cullin-1 (CUL1), Human, ELISA Kit - CSB-EL006218HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cullin-1 (CUL1), Human, ELISA Kit - E01C2181 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Cullin 1 Colorimetric Cell-Based ELISA Kit - CB5179 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

cullin 1, ELISA Kit - MBS921353 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CUL1 is typically less than 11.72 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 46.88 pg/ml-3000 pg/ml.

Cullin 1 (CUL1), ELISA Kit - MBS7220500 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7214383 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7216955 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7212119 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7240318 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7203712 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7208069 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7217046 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7246267 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7219907 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7229137 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cullin-1 (CUL1), ELISA Kit - MBS7210996 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Cullin-1(CUL1) ELISA kit - CSB-EL006218HU from Cusabio Category ELISA Kit Sensitivity 11.72 pg/ml Range Request Information

Cullin 1 ELISA Kit - DEIA-XYA490 from Creative Diagnostics Category ELISA Kit

Human Cullin-1(CUL1) ELISA Kit - EKC33331 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity Request Information Range Request Information

Human CUL1 ELISA Kit - E010378 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human CUL1 is typically less than 11.72 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

anti-Cullin-1 (CUL-1) antibody - ARG52913 from Arigo Biolaboratories Category ELISA Kit

anti-Cullin-1 (CUL-1) antibody (Ready-to-Use) - ARG52914 from Arigo Biolaboratories Category ELISA Kit

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