CUL1

Gene Symbol	CUL1
Entrez Gene	8454
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cullin 1
Other Description	CUL-1|cullin-1
Swissprots	D3DWG3 Q08AL6 O60719 Q13616 Q8IYW1
Accessions	AAM49153 AAS02034 EAL24422 EAW80072 EAW80073 EAW80074 Q13616 AF062536 AAC36681 AK096163 BAG53222 AK096505 BAG53307 AK296909 BAG59465 AK315023 AM393444 CAL38322 AM393566 CAL38443 BC034318 BC125119 AAI25120 BC125120 AAI25121 BG391038 BX537409 CAD97651 CA945052 U58087 AAC50544 XM_005250060 XP_005250117 XM_011516629 XP_011514931 XM_011516630 XP_011514932 XM_011516631 XP_011514933 XM_011516632 XP_011514934 NM_003592 NP_003583
Function	Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFK
Tissue Specificity	Expressed in lung fibroblasts. {ECO:0000269|PubMed:9663463}.
Top Pathways	Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cullin 1 full length protein - ab131835 from Abcam Category Protein Source Wheat germ Species Human

Human Cullin 1 protein fragment - ab91876 from Abcam Category Protein Source E. coli Species Human

Human Cullin 1 protein fragment - ab99960 from Abcam Category Protein Source E. coli Species Human

Cullin 1 / CUL1 Antibody Blocking Peptide - LS-E4084 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cullin 1 / CUL1 Antibody Blocking Peptide - LS-E10588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cullin 1 Protein - NBP1-49441 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E.coli Species Human

Cullin 1 Recombinant Protein - H00008454-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

CUL1-Antibody-C-term-Blocking-Peptide - BP16324b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CUL1 Protein (OPPA02515) - OPPA02515 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human CUL1 protein - orb168176 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

CUL1 Blocking Peptide - 33R-3827 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CUL1 protein (His tag) - 80R-1515 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

Cullin 1 Blocking Peptide - abx063473 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Rabbit

Cullin 1 (1-410, His-tag) - AR09691PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

Cullin 1 (1-410, His-tag) - AR09691PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

Cullin 1 - H00008454-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Cullin 1 - H00008454-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Cullin-1, Human Recombinant - 228-13020-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Cullin-1 - 228-13020-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Cullin-1 - 228-13020-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

CUL1, 1-410aa, Human, His tag, E.coli - 01-2389-1 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

CUL1 fusion protein - Ag3585 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CUL1 Human - PRPS-275 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human CutA Divalent Cation Tolerance Homolog Protein - BP001526-PRO-812 from Syd Labs Category Protein Prices $160.00, $2,250.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

CUL1, 1-410aa, Recombinant Protein - GWB-P1285K from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 50 μg, 250 μg Source E.coli Species Human

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