| Gene Symbol | CUL1 |
|---|---|
| Entrez Gene | 8454 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cullin 1 |
| Other Description | CUL-1|cullin-1 |
| Swissprots | D3DWG3 Q08AL6 O60719 Q13616 Q8IYW1 |
| Accessions | AAM49153 AAS02034 EAL24422 EAW80072 EAW80073 EAW80074 Q13616 AF062536 AAC36681 AK096163 BAG53222 AK096505 BAG53307 AK296909 BAG59465 AK315023 AM393444 CAL38322 AM393566 CAL38443 BC034318 BC125119 AAI25120 BC125120 AAI25121 BG391038 BX537409 CAD97651 CA945052 U58087 AAC50544 XM_005250060 XP_005250117 XM_011516629 XP_011514931 XM_011516630 XP_011514932 XM_011516631 XP_011514933 XM_011516632 XP_011514934 NM_003592 NP_003583 |
| Function | Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFK |
| Tissue Specificity | Expressed in lung fibroblasts. {ECO:0000269|PubMed:9663463}. |
| Top Pathways | Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm |