| Gene Symbol |
OBSL1
|
| Entrez Gene |
23363
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
obscurin-like 1
|
| Other Description |
obscurin-like protein 1
|
| Swissprots |
A4KVA4 A4KVA5 S4R3M6 Q96IW3 O75147
|
| Accessions |
O75147 AB014557 BAA31632 AF035292 AK023854 BAB14704 AK025946 AK299261 BAH12981 BC007201 AAH07201 BC061909 AAH61909 CK904385 DB475523 EF063637 ABO42327 EF063638 ABO42328 F30329 XM_005246424 XP_005246481 XM_005246427 XP_005246484 XM_011510854 XP_011509156 XM_011510855 XP_011509157 XM_011510856 XP_011509158 XM_011510857 XP_011509159 XM_011510858 XP_011509160 XM_011510859 XP_011509161 XM_011510860 XP_011509162 XM_011510861 XP_011509163 XM_011510862 XP_011509164 XM_011510863 XP_011509165 XM_011510864 XP_011509166 XM_011510865 XP_011509167 XM_011510866 XP_011509168 NM_001173408 NP_001166879 NM_001173431 NP_001166902 NM_015311 NP_056126
|
| Function |
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.
|
| Tissue Specificity |
Widely expressed, with predominant levels found in the heart. {ECO:0000269|PubMed:17289344}.
|