OBSL1

Gene Symbol OBSL1
Entrez Gene 23363
Alt Symbol -
Species Human
Gene Type protein-coding
Description obscurin-like 1
Other Description obscurin-like protein 1
Swissprots A4KVA4 A4KVA5 S4R3M6 Q96IW3 O75147
Accessions O75147 AB014557 BAA31632 AF035292 AK023854 BAB14704 AK025946 AK299261 BAH12981 BC007201 AAH07201 BC061909 AAH61909 CK904385 DB475523 EF063637 ABO42327 EF063638 ABO42328 F30329 XM_005246424 XP_005246481 XM_005246427 XP_005246484 XM_011510854 XP_011509156 XM_011510855 XP_011509157 XM_011510856 XP_011509158 XM_011510857 XP_011509159 XM_011510858 XP_011509160 XM_011510859 XP_011509161 XM_011510860 XP_011509162 XM_011510861 XP_011509163 XM_011510862 XP_011509164 XM_011510863 XP_011509165 XM_011510864 XP_011509166 XM_011510865 XP_011509167 XM_011510866 XP_011509168 NM_001173408 NP_001166879 NM_001173431 NP_001166902 NM_015311 NP_056126
Function Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.
Tissue Specificity Widely expressed, with predominant levels found in the heart. {ECO:0000269|PubMed:17289344}.

OBSL1 CRISPR/Cas9 KO Plasmid (h) - sc-407284 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 HDR Plasmid (h) - sc-407284-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 Double Nickase Plasmid (h) - sc-407284-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 Double Nickase Plasmid (h2) - sc-407284-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 CRISPR Activation Plasmid (h) - sc-407284-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 CRISPR Activation Plasmid (h2) - sc-407284-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 Lentiviral Activation Particles (h) - sc-407284-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OBSL1 Lentiviral Activation Particles (h2) - sc-407284-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MISSION® esiRNA - EHU099861 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15677 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15677 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

OBSL1 siRNA (Human) - CRH8212 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human OBSL1 (NM_015311.2) - SHH357168 from Creative biogene

Category siRNA
Species Reactivities Human

OBSL1 shRNA Plasmid (Human) - CHH8212 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

OBSL1 miRNA 3'UTR clone - MiUTR3H-11596 from Creative biogene

Species Reactivities Human
Search more