RAB23

Gene Symbol	RAB23
Entrez Gene	51715
Alt Symbol	HSPC137
Species	Human
Gene Type	protein-coding
Description	RAB23, member RAS oncogene family
Other Description	RAB family small GTP binding protein RAB 23|ras-related protein Rab-23
Swissprots	Q9ULC3 B2R9I5 Q8NI06 Q68DJ6 Q9P023
Accessions	EAX04476 EAX04477 EAX04478 EAX04479 Q9ULC3 AB025427 BAB40309 AB034244 BAA87324 AF161486 AAF29101 AF498951 AAM21099 AK311123 AK313796 BAG36532 AU280196 AY585189 AAT79492 BC015021 AAH15021 CR749371 CAH18224 DA021294 DA391757 DA997359 EU832304 ACE87561 EU832388 ACE86873 XM_005249179 XP_005249236 NM_001278666 NP_001265595 NM_001278667 NP_001265596 NM_001278668 NP_001265597 NM_016277 NP_057361 NM_183227 NP_899050 NR_103822
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:22452336}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Top Pathways	Hedgehog signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse RAB23 full length protein - ab90111 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli Species Mouse

Human RAB23 full length protein - ab117218 from Abcam Category Protein Source E. coli Species Human

RAB23 Antibody Blocking Peptide - LS-E26604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB23 Antibody Blocking Peptide - LS-E20715 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB23 Antibody Blocking Peptide - LS-E20716 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB23 Partial Recombinant Protein - H00051715-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RAB23 Recombinant Protein - H00051715-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RAB23 Protein - NBP1-72529 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

RAB23 blocking peptide - GTX88658-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Human RAB23 protein - orb169138 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Rab23 Blocking Peptide - 33R-2100 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAB23 Blocking Peptide - 33R-9136 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAB23 protein (His tag) - 80R-2032 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

RAB23 Blocking Peptide - abx063876 from Abbexa Category Peptide Species Human, Mouse

RAB23 Peptide - AC21-1440-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RAB23 (1-234, His-tag) - AR50115PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RAB23 (1-234, His-tag) - AR50115PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RAB23 - H00051715-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAB23 - H00051715-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAB23 - H00051715-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB23 - H00051715-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB23, Member RAS Oncogene Family, Human Recombinant - 228-13416-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human RAB23, Member RAS Oncogene Family - 228-13416-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source E.coli. Species Human

Recombinant Human RAB23, Member RAS Oncogene Family - 228-13416-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source E.coli. Species Human

RAB23, 1-234aa, Human, His tag E.coli - 01-RAB23 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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