| Gene Symbol | RAB23 |
|---|---|
| Entrez Gene | 51715 |
| Alt Symbol | HSPC137 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB23, member RAS oncogene family |
| Other Description | RAB family small GTP binding protein RAB 23|ras-related protein Rab-23 |
| Swissprots | Q9ULC3 B2R9I5 Q8NI06 Q68DJ6 Q9P023 |
| Accessions | EAX04476 EAX04477 EAX04478 EAX04479 Q9ULC3 AB025427 BAB40309 AB034244 BAA87324 AF161486 AAF29101 AF498951 AAM21099 AK311123 AK313796 BAG36532 AU280196 AY585189 AAT79492 BC015021 AAH15021 CR749371 CAH18224 DA021294 DA391757 DA997359 EU832304 ACE87561 EU832388 ACE86873 XM_005249179 XP_005249236 NM_001278666 NP_001265595 NM_001278667 NP_001265596 NM_001278668 NP_001265597 NM_016277 NP_057361 NM_183227 NP_899050 NR_103822 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:22452336}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. |
| Top Pathways | Hedgehog signaling pathway |
Rab 23 CRISPR/Cas9 KO Plasmid (h) - sc-416707 from Santa Cruz Biotechnology
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Rab 23 HDR Plasmid (h) - sc-416707-HDR from Santa Cruz Biotechnology
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Rab 23 Double Nickase Plasmid (h) - sc-416707-NIC from Santa Cruz Biotechnology
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Rab 23 Double Nickase Plasmid (h2) - sc-416707-NIC-2 from Santa Cruz Biotechnology
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Rab 23 CRISPR Activation Plasmid (h) - sc-416707-ACT from Santa Cruz Biotechnology
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Rab 23 CRISPR Activation Plasmid (h2) - sc-416707-ACT-2 from Santa Cruz Biotechnology
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Rab 23 Lentiviral Activation Particles (h) - sc-416707-LAC from Santa Cruz Biotechnology
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Rab 23 Lentiviral Activation Particles (h2) - sc-416707-LAC-2 from Santa Cruz Biotechnology
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Rab 23 siRNA (h) - sc-95163 from Santa Cruz Biotechnology
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Rab 23 shRNA Plasmid (h) - sc-95163-SH from Santa Cruz Biotechnology
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Rab 23 shRNA (h) Lentiviral Particles - sc-95163-V from Santa Cruz Biotechnology
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RAB23 RNAi - H00051715-R01 from Novus Biologicals
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MISSION® esiRNA - EHU157681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17821 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10214 from Sigma-Aldrich
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RAB23 siRNA (Human) - CRH9915 from Cohesion Biosciences
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RAB23 RNAi - H00051715-R02 from Novus Biologicals
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RAB23 - MBS8221072 from MyBioSource
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shRNA set against Human RAB23 (NM_183227.1) - SHH388052 from Creative biogene
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shRNA set against Human RAB23(NM_183227.1) - SHR158222 from Creative biogene
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shRNA set against Human RAB23(NM_016277.3) - SHR158304 from Creative biogene
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shRNA set against Human RAB23(NM_183227.1) - SHR158344 from Creative biogene
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RAB23 shRNA Plasmid (Human) - CHH9915 from Cohesion Biosciences
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RAB23 miRNA 3'UTR clone - MiUTR1H-08548 from Creative biogene
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