DDX21

Gene Symbol	DDX21
Entrez Gene	9188
Alt Symbol	GUA, GURDB, RH-II/GU, RH-II/GuA
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 21
Other Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21|DEAD box protein 21|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21|Gu protein|RH II/Gu|RNA helicase II/Gu alpha|gu-alpha|nucleolar RNA helicase 2|nucleolar RNA helicase Gu|nucleolar RNA helicase II
Swissprots	B2RDL0 Q5VX41 Q9NR30 Q68D35 Q13436
Accessions	AAF78930 EAW54305 EAW54306 EAW54307 Q9NR30 AA446317 AB062394 BAB93481 AK025629 AK315585 BAG37957 BC004182 BC008071 AAH08071 BC009432 BC017228 BC104671 AAI04672 BU963561 BX648405 CR749598 CAH18395 DQ893631 ABM84557 DQ896852 ABM87851 DW408689 U41387 AAB02546 XM_011540336 XP_011538638 NM_001256910 NP_001243839 NM_004728 NP_004719
Function	RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'- O-methylation, possibly by promoting the recruitment of late- acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for ph
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:8614622}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060}. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DDX21 (D-8) - sc-376953 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DDX21 (H-94) - sc-98643 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DDX21 (L-12) - sc-104860 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DDX21 (W-15) - sc-104862 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DDX21 (K-23) - sc-133503 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-DDX21 antibody - ab84394 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 antibody - ab130709 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 antibody [EPR14495] - ab182156 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14495

Anti-DDX21 antibody [EPR14496] - ab181870 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14496

Anti-DDX21 Antibody (aa1-50) - LS-C64595 from LifeSpan Bioscience Prices $545.00 Sizes 20 µg Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa50-100) - LS-C64596 from LifeSpan Bioscience Prices $545.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156, AP) - LS-C213531 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156, Biotin) - LS-C213533 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156, FITC) - LS-C213534 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156, APC) - LS-C213532 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156, Azide-free, HRP) - LS-C213535 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (C-Terminus) - LS-C31419 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (N-Terminus) - LS-C30092 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156, PE) - LS-C213536 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa1-50) - LS-C287500 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa50-100) - LS-C287501 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa127-156) - LS-C320784 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (aa128-156) - LS-C159446 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody - LS-C334460 from LifeSpan Bioscience Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DDX21 Antibody (C-Terminus) - LS-C287502 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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