DDX21

Gene Symbol	DDX21
Entrez Gene	9188
Alt Symbol	GUA, GURDB, RH-II/GU, RH-II/GuA
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 21
Other Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21|DEAD box protein 21|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21|Gu protein|RH II/Gu|RNA helicase II/Gu alpha|gu-alpha|nucleolar RNA helicase 2|nucleolar RNA helicase Gu|nucleolar RNA helicase II
Swissprots	B2RDL0 Q5VX41 Q9NR30 Q68D35 Q13436
Accessions	AAF78930 EAW54305 EAW54306 EAW54307 Q9NR30 AA446317 AB062394 BAB93481 AK025629 AK315585 BAG37957 BC004182 BC008071 AAH08071 BC009432 BC017228 BC104671 AAI04672 BU963561 BX648405 CR749598 CAH18395 DQ893631 ABM84557 DQ896852 ABM87851 DW408689 U41387 AAB02546 XM_011540336 XP_011538638 NM_001256910 NP_001243839 NM_004728 NP_004719
Function	RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'- O-methylation, possibly by promoting the recruitment of late- acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for ph
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:8614622}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060}. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDX21 full length protein - ab152960 from Abcam Category Protein Source Wheat germ Species Human

DDX21 Antibody Blocking Peptide - LS-E4858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX21 Antibody Blocking Peptide - LS-E13023 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX21 Antibody Blocking Peptide - LS-E13024 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DDX21 Protein - H00009188-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DDX21-Antibody-N-term-Blocking-Peptide - BP17238a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDX21 Blocking Peptide - 33R-3047 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX21 Blocking Peptide - 33R-6280 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX56 protein (His tag) - 80R-3491 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

DDX21 - H00009188-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

DDX21 fusion protein - Ag0804 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DDX21 fusion protein - Ag17741 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DDX21 fusion protein - Ag17850 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human DDX21, GST-tagged - DDX21-11895H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Nucleolar RNA helicase 2(DDX21) - CSB-YP882081HU CSB-EP882081HU CSB-BP882081HU CSB-MP882081HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DDX21 - TP300917 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DDX21 Recombinant Protein Antigen - NBP1-83310PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDX21 Recombinant Protein Antigen - NBP2-38311PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDX21 Peptide, Human - M34GP04142H from Creative Peptides Category Peptide Source Synthetic. Species Human

DDX56 - PAT-82357-1 from Nordic BioSite Category Protein Species Human

DDX56 - PAT-82357-2 from Nordic BioSite Category Protein Species Human

Nucleolar RNA helicase 2 (DDX21), Recombinant Protein - MBS1485072 from MyBioSource Category Protein Prices $1,615.00, $1,615.00, $1,845.00, $1,845.00, $2,725.00, $2,725.00, $3,180.00, $3,180.00, $3,180.00, $5,385.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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