| Gene Symbol |
DDX21
|
| Entrez Gene |
9188
|
| Alt Symbol |
GUA, GURDB, RH-II/GU, RH-II/GuA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAD (Asp-Glu-Ala-Asp) box helicase 21
|
| Other Description |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21|DEAD box protein 21|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21|Gu protein|RH II/Gu|RNA helicase II/Gu alpha|gu-alpha|nucleolar RNA helicase 2|nucleolar RNA helicase Gu|nucleolar RNA helicase II
|
| Swissprots |
B2RDL0 Q5VX41 Q9NR30 Q68D35 Q13436
|
| Accessions |
AAF78930 EAW54305 EAW54306 EAW54307 Q9NR30 AA446317 AB062394 BAB93481 AK025629 AK315585 BAG37957 BC004182 BC008071 AAH08071 BC009432 BC017228 BC104671 AAI04672 BU963561 BX648405 CR749598 CAH18395 DQ893631 ABM84557 DQ896852 ABM87851 DW408689 U41387 AAB02546 XM_011540336 XP_011538638 NM_001256910 NP_001243839 NM_004728 NP_004719
|
| Function |
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'- O-methylation, possibly by promoting the recruitment of late- acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for ph
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:8614622}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060}. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:23848194}.
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