Gene Symbol | GCG |
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Entrez Gene | 2641 |
Alt Symbol | GLP1, GLP2, GRPP |
Species | Human |
Gene Type | protein-coding |
Description | glucagon |
Other Description | glicentin-related polypeptide|glucagon-like peptide 1|glucagon-like peptide 2|preproglucagon |
Swissprots | A6NN65 P01275 Q53TP6 |
Accessions | AAY24204 CAA24759 CAA27627 EAX11356 EAX11357 EAX11358 P01275 AI818268 BC005278 AAH05278 BG654603 BM272442 BT006813 AAP35459 CB069629 DQ892521 ABM83447 DQ895732 ABM86658 J04040 AAA52567 X05386 X05388 NM_002054 NP_002045 |
Function | Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. |
Subcellular Location | Secreted. |
Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain. |
Top Pathways | Glucagon signaling pathway |
proglucagon CRISPR/Cas9 KO Plasmid (h) - sc-416721 from Santa Cruz Biotechnology
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proglucagon HDR Plasmid (h) - sc-416721-HDR from Santa Cruz Biotechnology
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proglucagon Double Nickase Plasmid (h) - sc-416721-NIC from Santa Cruz Biotechnology
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proglucagon Double Nickase Plasmid (h2) - sc-416721-NIC-2 from Santa Cruz Biotechnology
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proglucagon CRISPR Activation Plasmid (h) - sc-416721-ACT from Santa Cruz Biotechnology
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proglucagon CRISPR Activation Plasmid (h2) - sc-416721-ACT-2 from Santa Cruz Biotechnology
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proglucagon Lentiviral Activation Particles (h) - sc-416721-LAC from Santa Cruz Biotechnology
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proglucagon Lentiviral Activation Particles (h2) - sc-416721-LAC-2 from Santa Cruz Biotechnology
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Proglucagon siRNA (h) - sc-39528 from Santa Cruz Biotechnology
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Proglucagon shRNA Plasmid (h) - sc-39528-SH from Santa Cruz Biotechnology
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Proglucagon shRNA (h) Lentiviral Particles - sc-39528-V from Santa Cruz Biotechnology
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Glucagon RNAi - H00002641-R01 from Novus Biologicals
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MISSION® esiRNA - EHU005721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9185 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9185 from Sigma-Aldrich
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GCG siRNA (Human) - CRH1755 from Cohesion Biosciences
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GCG - MBS8201929 from MyBioSource
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shRNA set against Human GCG (NM_002054.4) - SHH299974 from Creative biogene
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Human GCG siRNA - orb262257 from Biorbyt
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GCG shRNA Plasmid (Human) - CHH1755 from Cohesion Biosciences
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GCG miRNA 3'UTR clone - MiUTR4H-TG03755 from Creative biogene
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