| Gene Symbol |
STRADA
|
| Entrez Gene |
92335
|
| Alt Symbol |
LYK5, NY-BR-96, PMSE, STRAD, Stlk
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
STE20-related kinase adaptor alpha
|
| Other Description |
STE20-like pseudokinase|STE20-related kinase adapter protein alpha|STRAD alpha|protein kinase LYK5|serologically defined breast cancer antigen NY-BR-96
|
| Swissprots |
J3KTC9 Q7RTN6 Q7Z4K9 B4DW17 Q8NC31 Q8NCF1 B4DDE3 Q9H272 Q5JPI2
|
| Accessions |
CAF85943 EAW94283 EAW94284 EAW94285 EAW94286 EAW94287 EAW94288 EAW94289 EAW94290 Q7RTN6 AF308302 AAG48269 AK074771 BAC11197 AK075005 BAC11349 AK128173 AK293160 BAG56704 AK301331 BAG62879 AL832407 CAI46194 AY290821 AAP42280 BC043641 AAH43641 BG339051 BK001542 DAA01797 BQ682133 XM_005257797 XP_005257854 XM_005257798 XP_005257855 XM_005257799 XP_005257856 XM_005257800 XP_005257857 XM_005257801 XP_005257858 XM_005257803 XP_005257860 XM_011525466 XP_011523768 XM_011525467 XP_011523769 XR_243687 XR_243688 NM_001003786 NP_001003786 NM_001003787 NP_001003787 NM_001003788 NP_001003788 NM_001165969 NP_001159441 NM_001165970 NP_001159442 NM_153335 NP_699166
|
| Function |
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}.
|
| Top Pathways |
AMPK signaling pathway, mTOR signaling pathway
|