S1PR4

Gene Symbol S1PR4
Entrez Gene 8698
Alt Symbol EDG6, LPC1, S1P4, SLP4
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate receptor 4
Other Description S1P receptor 4|S1P receptor Edg-6|endothelial differentiation G-protein coupled receptor 6|endothelial differentiation, G protein coupled receptor 6|endothelial differentiation, G-protein-coupled receptor 6|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6|sphingosine 1-phosphate receptor 4|sphingosine 1-phosphate receptor Edg-6
Swissprots O95977 D6W612
Accessions AAP84350 EAW69336 EAW69337 O95977 AJ000479 CAA04118 BC014970 AAH14970 FJ200495 ACO54892 NM_003775 NP_003766
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
Top Pathways Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

EDG-6 (H-57) - sc-366771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

EDG-6 (T-20) - sc-22306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EDG-6 (C-20) - sc-16088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EDG-6 (1) - sc-65216 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
EDG-6 (1) : sc-65216. Western blot analysis of EDG-6 expression in human EDG-6 transfected whole cell lysate.

Anti-EDG6 antibody - ab126392 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EDG6 antibody (ab126392) at 1 µg/mlLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-EDG6 antibody - ab89277 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-EDG6 antibody (ab89277) at 1 µg/ml + Jurkat cell lysate at 50 µgdeveloped using the ECL technique

Anti-EDG6 antibody - ab96501 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-EDG6 antibody (ab96501) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-EDG6 antibody - ab135963 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EDG6 antibody (ab135963) at 1/500 dilution + HT29 cell lysate at 30 µg

Anti-EDG6 antibody - N-terminal - ab200164 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EDG6 antibody - N-terminal (ab200164) at 1/1000 dilutionLane 1 : Total cell extracts from mouse thymusLane 2 : Total cell extracts from Human Jurkat

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa326-375) - LS-C120578 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using EDG6 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-S1PR4 / SIP4 / EDG6 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A71 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR4 / EDG6 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A71 dilution 9.6 ug/ml.

Anti-S1PR4 / SIP4 / EDG6 Antibody IHC-plus™ - LS-B513 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EDG6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B513 concentration 10 ug/ml.

Anti-S1PR4 / SIP4 / EDG6 Antibody (C-Terminus) - LS-C6473 from LifeSpan Bioscience

Prices $755.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (N-Terminus) - LS-C26785 from LifeSpan Bioscience

Prices $570.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (FITC) - LS-C26795 from LifeSpan Bioscience

Prices $570.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa320-384) - LS-C185959 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa1-50) - LS-C190742 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa15-45, APC) - LS-C213643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa15-45, Biotin) - LS-C213644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa15-45, AP) - LS-C213645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa15-45, Azide-free, HRP) - LS-C213647 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody (aa15-45, FITC) - LS-C213646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR4 / SIP4 / EDG6 Antibody - LS-C26764 from LifeSpan Bioscience

Prices $570.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot of EDG6 (S1P4) monoclonal antibody (LS-C26764) on cell lysate transfected with EDG6 (S1P4) protein at 5 ug/ml. IF on transiently transfected CHO cells. Developed with Cy5 anti-mouse, nuclei are stained with DAPI.

Anti-S1PR4 / SIP4 / EDG6 Antibody (C-Terminus) IHC-plus™ - LS-A70 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR4 / EDG6 antibody LS-A70 IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-S1PR4 / SIP4 / EDG6 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A72 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR4 / EDG6 antibody LS-A72 IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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