| Gene Symbol |
S1PR4
|
| Entrez Gene |
8698
|
| Alt Symbol |
EDG6, LPC1, S1P4, SLP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate receptor 4
|
| Other Description |
S1P receptor 4|S1P receptor Edg-6|endothelial differentiation G-protein coupled receptor 6|endothelial differentiation, G protein coupled receptor 6|endothelial differentiation, G-protein-coupled receptor 6|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6|sphingosine 1-phosphate receptor 4|sphingosine 1-phosphate receptor Edg-6
|
| Swissprots |
O95977 D6W612
|
| Accessions |
AAP84350 EAW69336 EAW69337 O95977 AJ000479 CAA04118 BC014970 AAH14970 FJ200495 ACO54892 NM_003775 NP_003766
|
| Function |
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
|
| Top Pathways |
Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction
|