| Gene Symbol |
POLR3K
|
| Entrez Gene |
51728
|
| Alt Symbol |
C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
|
| Other Description |
DNA-directed RNA polymerase III subunit K|DNA-directed RNA polymerase III subunit RPC10|DNA-directed RNA polymerases III 12.5 kDa polypeptide|RNA polymerase III 12.5 kDa subunit|RNA polymerase III subunit C10|RNA polymerase III subunit C11|RNA polymerase III subunit CII
|
| Swissprots |
Q9Y2Y1 Q96S35 Q1W6H4
|
| Accessions |
AAD31424 AAK61210 ABD95903 CAI95605 CCO13792 EAW85879 Q9Y2Y1 AF051316 AAF18268 AF060223 AAG43123 BC011932 AAH11932 DQ896281 ABM87280 DR978472 EU176418 ABW03869 NM_016310 NP_057394
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|