POLR3K

Gene Symbol	POLR3K
Entrez Gene	51728
Alt Symbol	C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
Other Description	DNA-directed RNA polymerase III subunit K|DNA-directed RNA polymerase III subunit RPC10|DNA-directed RNA polymerases III 12.5 kDa polypeptide|RNA polymerase III 12.5 kDa subunit|RNA polymerase III subunit C10|RNA polymerase III subunit C11|RNA polymerase III subunit CII
Swissprots	Q9Y2Y1 Q96S35 Q1W6H4
Accessions	AAD31424 AAK61210 ABD95903 CAI95605 CCO13792 EAW85879 Q9Y2Y1 AF051316 AAF18268 AF060223 AAG43123 BC011932 AAH11932 DQ896281 ABM87280 DR978472 EU176418 ABW03869 NM_016310 NP_057394
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLR3K full length protein - ab162651 from Abcam Category Protein Source Wheat germ Species Human

Human POLR3K full length protein - ab180315 from Abcam Category Protein Source E. coli Species Human

POLR3K Recombinant Protein - H00051728-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human POLR3K protein - orb244451 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

POLR3K protein (His tag) - 80R-3892 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

POLR3K Blocking Peptide - abx064257 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig

POLR3K (1-108, His-tag) - AR51579PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

POLR3K (1-108, His-tag) - AR51579PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

POLR3K - H00051728-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POLR3K - H00051728-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POLR3K, 1-108aa, Human, His tag, E.coli - 01-P2759 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

POLR3K fusion protein - Ag1564 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human POLR3K, His-tagged - POLR3K-266H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human POLR3K, GST-tagged - POLR3K-1852H from Creative Biomart Category Protein Source E.coli Species Human

POLR3K Blocking Peptide - CBP3063 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig

Recombinant human DNA-directed RNA polymerase III subunit RPC10 - CSB-YP018352HU CSB-BP018352HU CSB-MP018352HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human DNA-directed RNA polymerase III subunit RPC10 - CSB-EP018352HU from Cusabio Category Protein Source E.coli Species Human

POLR3K, 1-108aa, Human, His tag, E.coli - ATGP2759 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

POLR3K - TP304102 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

POLR3K, Recombinant Protein - MBS205528 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 20 µg, 100 µg Source E Coli Species Human

Polymerase III Polypeptide K, Recombinant Protein - MBS146426 from MyBioSource Category Protein Prices $140.00, $205.00, $1,220.00 Sizes 2 µg, 10 µg, 100 µg

POLR3K Recombinant Protein Antigen - NBP1-80815PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

POLR3K Peptide, Human - M34GP12113H from Creative Peptides Category Peptide Source Synthetic. Species Human

POLR3K Recombinant Protein (OPCA01791) - OPCA01791 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

POLR3K enzyme - orb259763 from Biorbyt Category Protein Prices $230.00, $442.00, $1,811.00 Sizes 2 μg, 10 μg, 100 μg Species Human

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