POLR3K

Gene Symbol	POLR3K
Entrez Gene	51728
Alt Symbol	C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
Other Description	DNA-directed RNA polymerase III subunit K|DNA-directed RNA polymerase III subunit RPC10|DNA-directed RNA polymerases III 12.5 kDa polypeptide|RNA polymerase III 12.5 kDa subunit|RNA polymerase III subunit C10|RNA polymerase III subunit C11|RNA polymerase III subunit CII
Swissprots	Q9Y2Y1 Q96S35 Q1W6H4
Accessions	AAD31424 AAK61210 ABD95903 CAI95605 CCO13792 EAW85879 Q9Y2Y1 AF051316 AAF18268 AF060223 AAG43123 BC011932 AAH11932 DQ896281 ABM87280 DR978472 EU176418 ABW03869 NM_016310 NP_057394
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POLR3K CRISPR/Cas9 KO Plasmid (h) - sc-412241 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K HDR Plasmid (h) - sc-412241-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K Double Nickase Plasmid (h) - sc-412241-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K Double Nickase Plasmid (h2) - sc-412241-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K CRISPR Activation Plasmid (h) - sc-412241-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K CRISPR Activation Plasmid (h2) - sc-412241-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K Lentiviral Activation Particles (h) - sc-412241-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K Lentiviral Activation Particles (h2) - sc-412241-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

POLR3K siRNA (h) - sc-93095 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

POLR3K shRNA Plasmid (h) - sc-93095-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

POLR3K shRNA (h) Lentiviral Particles - sc-93095-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

POLR3K RNAi - H00051728-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU156281 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1773 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1774 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1775 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN17135 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17135 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

POLR3K siRNA (Human) - CRH9921 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human POLR3K (NM_016310.3) - SHH379636 from Creative biogene Category siRNA Species Reactivities Human

Human POLR3K siRNA - orb270423 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

POLR3K shRNA Plasmid (Human) - CHH9921 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

POLR3K miRNA 3'UTR clone - MiUTR3H-08131 from Creative biogene Species Reactivities Human

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