| Gene Symbol |
SETD1A
|
| Entrez Gene |
9739
|
| Alt Symbol |
KMT2F, Set1, Set1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET domain containing 1A
|
| Other Description |
SET domain-containing protein 1A|hSET1A|histone-lysine N-methyltransferase SETD1A|lysine N-methyltransferase 2F|set1/Ash2 histone methyltransferase complex subunit SET1
|
| Swissprots |
O15047 A6NP62 Q8TAJ6 Q6PIF3
|
| Accessions |
CCO13810 O15047 AB002337 BAA20797 BC027450 AAH27450 BC035795 AAH35795 XM_005255723 XP_005255780 XM_006721106 XP_006721169 XM_011545994 XP_011544296 XM_011545995 XP_011544297 XM_011545996 XP_011544298 NM_014712 NP_055527
|
| Function |
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. {ECO:0000269|PubMed:12670868}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
|
| Top Pathways |
Lysine degradation
|