SETD1A

Gene Symbol	SETD1A
Entrez Gene	9739
Alt Symbol	KMT2F, Set1, Set1A
Species	Human
Gene Type	protein-coding
Description	SET domain containing 1A
Other Description	SET domain-containing protein 1A|hSET1A|histone-lysine N-methyltransferase SETD1A|lysine N-methyltransferase 2F|set1/Ash2 histone methyltransferase complex subunit SET1
Swissprots	O15047 A6NP62 Q8TAJ6 Q6PIF3
Accessions	CCO13810 O15047 AB002337 BAA20797 BC027450 AAH27450 BC035795 AAH35795 XM_005255723 XP_005255780 XM_006721106 XP_006721169 XM_011545994 XP_011544296 XM_011545995 XP_011544297 XM_011545996 XP_011544298 NM_014712 NP_055527
Function	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. {ECO:0000269|PubMed:12670868}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human Histone-lysine N-methyltransferase SETD1A(SETD1A) ,partial - CSB-YP021101HU CSB-EP021101HU CSB-BP021101HU CSB-MP021101HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human SET1A Complex Protein, His/GST-tagged - SETD1A-184H from Creative Biomart Category Protein Source E.coli Species Human

SETD1A Recombinant Protein Antigen - NBP1-81513PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SETD1A Recombinant Protein Antigen - NBP2-49281PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

SET1-Antibody-C-term-Blocking-Peptide - BP1195b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SET1-Antibody-N-term-Blocking-Peptide - BP1195a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETD1A-Blocking-PeptideCenter - BP19714c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETD1A Peptide, Human - M34GP14077H from Creative Peptides Category Peptide Source Synthetic. Species Human

Histone-lysine N-methyltransferase SETD1A (SETD1A), partial, Recombinant Protein - MBS1257508 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SETD1A, Recombinant Protein - MBS515667 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

SETD1A, Recombinant Protein - MBS515668 from MyBioSource Category Protein Prices $315.00, $425.00 Sizes 5 µg, 10 µg Source Sf9 insect cells using baculovirus Species Human

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